Airaksinen P J, Valkonen R, Stenborg T, Takki K, Klemetti A, Kontkanen M, Oskala P
Department of Ophthalmology, University of Oulu, Finland.
Am J Ophthalmol. 1987 Dec 15;104(6):587-90. doi: 10.1016/0002-9394(87)90168-1.
In a double-masked, randomized, multicenter study, 25 patients received timolol 0.5%-pilocarpine 2% twice a day, 25 received timolol 0.5%-pilocarpine 4% twice a day, and 25 received pilocarpine 4% four times a day. The combination drugs showed an immediate, significant reduction in intraocular pressure of 7.2 mm Hg (25%) and 10.7 mm Hg (37%), respectively. The lowered intraocular pressure level was maintained throughout the three-week test period. With pilocarpine alone, intraocular pressure was reduced 5.3 mm Hg (19%). The mean intraocular pressure 12 hours after the last dose compared to two hours after the last dose was significantly higher both in patients receiving pilocarpine four times a day and in patients receiving timolol 0.5%-pilocarpine 4% twice a day (5.1 and 3.6 mm Hg, respectively), but not in patients receiving timolol 0.5%-pilocarpine 2% twice a day (2.6 mm Hg).
在一项双盲、随机、多中心研究中，25名患者每天两次使用0.5%噻吗洛尔-2%毛果芸香碱，25名患者每天两次使用0.5%噻吗洛尔-4%毛果芸香碱，25名患者每天四次使用4%毛果芸香碱。联合用药分别使眼压立即显著降低7.2毫米汞柱（25%）和10.7毫米汞柱（37%）。在整个三周的测试期内，降低后的眼压水平得以维持。单独使用毛果芸香碱时，眼压降低了5.3毫米汞柱（19%）。与最后一剂用药后两小时相比，每天四次使用毛果芸香碱的患者和每天两次使用0.5%噻吗洛尔-4%毛果芸香碱的患者在最后一剂用药后12小时的平均眼压显著更高（分别为5.1和3.6毫米汞柱），但每天两次使用0.5%噻吗洛尔-2%毛果芸香碱的患者则不然（2.6毫米汞柱）。
