朗格汉斯细胞：HIV 限制和传播的“阴阳”。
Langerhans Cells: the 'Yin and Yang' of HIV Restriction and Transmission.
机构信息
INSERM U1109, FMTS, University of Strasbourg, 3 rue Koeberlé, Strasbourg 67000, France.
Beijing Key Laboratory for HIV/AIDS Research, Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China.
出版信息
Trends Microbiol. 2017 Mar;25(3):170-172. doi: 10.1016/j.tim.2017.01.009. Epub 2017 Feb 9.
Langerhans cells are specialized sentinels present in the epidermis expressing Langerin, a specific C-type lectin receptor involved in HIV capture and destruction. Recently, the specific mechanism leading to this HIV restriction was discovered. Nevertheless, Langerhans cells can be infected and the way HIV escapes this restriction needs to be unraveled.
朗格汉斯细胞是存在于表皮中的特化哨兵细胞，表达朗格汉斯糖蛋白，这是一种参与 HIV 捕获和破坏的特异性 C 型凝集素受体。最近，发现了导致这种 HIV 限制的具体机制。然而，朗格汉斯细胞也可能被感染，需要阐明 HIV 逃避这种限制的方式。
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