Ganjali Shiva, Blesso Christopher N, Banach Maciej, Pirro Matteo, Majeed Muhammed, Sahebkar Amirhossein
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States.
Pharmacol Res. 2017 May;119:208-218. doi: 10.1016/j.phrs.2017.02.008. Epub 2017 Feb 10.
Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.
姜黄素是一种具有生物活性的多酚，是姜黄植物的黄色色素。姜黄素具有多种药理作用，包括抗氧化、抗癌、抗肥胖、抗血管生成和抗炎特性。最近发现，姜黄素会影响脂质代谢，进而可能缓解高脂血症和动脉粥样硬化。血浆高密度脂蛋白胆固醇（HDL-C）是心血管疾病（CVD）的一个独立的负性风险预测指标。然而，众多临床和遗传学研究在提高血浆HDL-C水平的治疗益处方面均得出了令人失望的结果。因此，目前的研究工作集中在改善HDL功能上，而不依赖于HDL-C水平。由于组成的异质性，HDL颗粒的质量可能有很大差异。与其在组成和代谢方面的复杂性相一致，HDL具有广泛的生物活性，包括抗氧化、抗糖化、抗炎、抗血栓形成、抗凋亡和免疫调节活性。姜黄素的保护特性可能会影响HDL功能；因此，我们查阅了文献，以确定姜黄素是否能增强HDL功能。在本综述中，我们得出结论，姜黄素可能会调节HDL功能的标志物，如载脂蛋白AI、胆固醇酯转运蛋白（CETP）、卵磷脂胆固醇酰基转移酶（LCAT）、对氧磷酶1（PON1）、髓过氧化物酶（MPO）的活性和水平。姜黄素随后可能会改善HDL功能失调的状况，并且在未来可能具有作为治疗药物的潜力。有必要对生物利用度提高的姜黄素制剂进行进一步的临床试验，以研究其对脂质代谢和HDL功能的影响。
