比较纯棕榈油、含氢化油的棕榈油和菜籽油对食用这些油的大鼠血清脂质和脂质氧化速率的影响。

Comparison of Pure Palm Olein Oil, Hydrogenated Oil-Containing Palm, and Canola on Serum Lipids and Lipid Oxidation Rate in Rats Fed with these Oils.

机构信息

Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

出版信息

Arch Iran Med. 2017 Feb;20(2):96-100.

PMID:28193083

Abstract

BACKGROUND

Due to increased consumption of canola oil and hydrogenated oil containing palm and palm olein, and their possible effects on serum lipoproteins, the present study was conducted to determine the effects of these oils on lipids and lipid oxidation level.

METHODS

In this experimental study, 88 Wistar rats were randomly assigned to four groups. Control group (A) was on a normal diet. Groups B, C, and D, in addition to normal diet, were fed with hydrogenated oil-contained palm oil, pure palm olein oil, and canola oil, respectively for 4 weeks. Serum Biochemical factors [total cholesterol (TC), triglyceride (TG), LDL, HDL, LDL/HDL ratio, oxLDL, paraoxanase-1 (PON1), and malondialdehyde (MDA)] were measured.

RESULTS

The lowest mean serum TC was seen in the control group and the highest in the group B. There were differences in TC, TG, HDL, MDA, and PON1 between the control group and other groups (P<0.001). The lowest and highest LDL/HDL ratios were observed in the group C and the control group, respectively. Significant differences were seen in OxLDL and PON1 between the control group and other three groups (P<0.05), while there were no significant differences in oxLDL and PON1 among the other three groups (P>0.05). MDA was higher in groups C and D.

CONCLUSION

Canola oil, hydrogenated oil-containing palm and palm olein may increase atherosclerosis risk through decreasing PON1 activity and elevating oxLDL. Palm olein oils in rats' diets cause a considerable decrease in LDL and help to increase HDL.

摘要

背景

由于菜籽油和含棕榈油及棕榈仁油的氢化油的消费增加，以及它们对血清脂蛋白的可能影响，本研究旨在确定这些油对脂质和脂质氧化水平的影响。

方法

在这项实验研究中，将 88 只 Wistar 大鼠随机分为 4 组。对照组（A）给予正常饮食。B、C 和 D 组除给予正常饮食外，分别给予含氢化棕榈油、纯棕榈仁油和菜籽油，喂养 4 周。测定血清生化指标[总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、LDL/HDL 比值、氧化低密度脂蛋白（oxLDL）、对氧磷酶 1（PON1）和丙二醛（MDA）]。

结果

TC 均值最低见于对照组，最高见于 B 组。TC、TG、HDL、MDA 和 PON1 均存在对照组与其他组之间的差异（P<0.001）。LDL/HDL 比值最低见于 C 组，最高见于对照组。对照组与其他三组之间的 oxLDL 和 PON1 存在显著差异（P<0.05），而其他三组之间的 oxLDL 和 PON1 无显著差异（P>0.05）。C 组和 D 组 MDA 较高。