线粒体钙单向转运体：结构、功能与药理学
The Mitochondrial Ca Uniporter: Structure, Function, and Pharmacology.
作者信息
Mishra Jyotsna, Jhun Bong Sook, Hurst Stephen, O-Uchi Jin, Csordás György, Sheu Shey-Shing
机构信息
Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Suite 543D, Philadelphia, PA, 19107, USA.
Cardiovascular Research Center, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
出版信息
Handb Exp Pharmacol. 2017;240:129-156. doi: 10.1007/164_2017_1.
Abstract
Mitochondrial Ca uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca uptake and our current understanding of mitochondrial Ca homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca uniporter complex.
摘要
线粒体钙摄取对于一系列细胞功能至关重要，而失衡则可引发细胞死亡。在本章中，我们简要回顾了线粒体钙摄取的各种模式以及目前我们对线粒体钙稳态在细胞生理和病理生理方面的理解。此外，本章重点关注线粒体钙单向转运体复合物的分子特性、细胞内调节因子以及药理学。
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