Gately L, McLachlan S A, Dowling A, Philip J
Department of Medical Oncology, St Vincent's Hospital, Melbourne, Australia.
Centre for Palliative Care, St Vincent's Hospital, Melbourne, Australia.
J Cancer Surviv. 2017 Aug;11(4):447-452. doi: 10.1007/s11764-017-0602-7. Epub 2017 Feb 13.
The median survival of glioblastoma is 12-14 months with less than 10% of patients surviving at least 2 years from diagnosis. Patients diagnosed with glioblastoma face poor prognosis, significant symptom burden, and high care needs. The aim of this study is to undertake a literature review to document the issues encountered by long-term survivors of glioblastoma, a small but important subset of patients.
MEDLINE, PsychInfo, and EMBASE were searched with core concepts: (1) glioblastoma, (2) survivor, and (3) terms pertaining to survivorship issues. A thematic analysis was undertaken of the three included studies.
Long-term survivors of glioblastoma encounter neurologic deficits, impairment in cognition, psychological distress, reduced social function, and future uncertainty. These issues result in the inability to return to work and financial difficulties. Independence in activities of daily living, working memory, and overall quality of life appears to be preserved.
Long-term survivors of glioblastoma continue to have significant symptom burden and care needs. There is currently a paucity of literature surrounding this topic. Further research is required to accurately describe these issues in order for improved supportive care to be implemented in the community and the outpatient setting.
Understanding the issues faced by long-term survivor of glioblastoma will provide insight into the care needs of patients as well as support networks required for patients and their carers.
胶质母细胞瘤患者的中位生存期为12 - 14个月，确诊后存活至少2年的患者不到10%。被诊断为胶质母细胞瘤的患者预后较差，症状负担重，护理需求高。本研究的目的是进行文献综述，以记录胶质母细胞瘤长期幸存者（这是一个虽小但很重要的患者亚组）所面临的问题。
在MEDLINE、PsychInfo和EMBASE数据库中进行检索，检索核心概念为：（1）胶质母细胞瘤，（2）幸存者，（3）与生存问题相关的术语。对纳入的三项研究进行了主题分析。
胶质母细胞瘤长期幸存者存在神经功能缺损、认知障碍、心理困扰、社交功能减退以及未来不确定性。这些问题导致他们无法重返工作岗位并陷入经济困难。日常生活活动能力、工作记忆和总体生活质量方面的独立性似乎得以保留。
胶质母细胞瘤长期幸存者仍有显著的症状负担和护理需求。目前关于这一主题的文献较少。需要进一步研究以准确描述这些问题，以便在社区和门诊环境中实施更好的支持性护理。
了解胶质母细胞瘤长期幸存者所面临的问题，将有助于深入了解患者的护理需求以及患者及其护理者所需的支持网络。
