Reader T A, Dewar K M, Grondin L
Département de Physiologie, Faculté de Médecine, Université de Montréal, Québec, Canada.
Brain Res Bull. 1989 Sep;23(3):237-47. doi: 10.1016/0361-9230(89)90153-6.
The monoamines noradrenaline (NA), dopamine (DA), adrenaline (AD) and 5-hydroxytryptamine (5-HT) were assayed in the putamen (PUT), the lateral (lCAU) and medial (mCAU) portions of the caudate, the dorsal (dHIP) and ventral (vHIP) hippocampus, as well as in four cortical areas, i.e., anterior cingulate (CIN), entorhinal-piriform (EnPi), sensorimotor (SSC; somatosensory) and primary visual (VIS). The use of an HPLC procedure enabled us to perform these measurements in microdissected samples and to assay as well monoamine metabolites. The DA levels were highest in the neostriatum, moderate in the EnPi and CIN and very low in the SSC, VIS and hippocampus. The distribution of NA was more uniform, although higher concentrations were measured in the neostriatum, hippocampus and EnPi. The largest amounts of 5-HT were in the EnPi, while moderate concentrations were found in the other regions. The ratios between the neurotransmitters and their metabolites were used as an index of turnover and indicate that the terminal fields of the monoamine systems are heterogenous within the neostriatal, hippocampal and cortical subdivisions.
对壳核（PUT）、尾状核的外侧（lCAU）和内侧（mCAU）部分、背侧（dHIP）和腹侧（vHIP）海马体以及四个皮质区域，即前扣带回（CIN）、内嗅-梨状区（EnPi）、感觉运动区（SSC；躯体感觉区）和初级视觉区（VIS）中的单胺类物质去甲肾上腺素（NA）、多巴胺（DA）、肾上腺素（AD）和5-羟色胺（5-HT）进行了测定。采用高效液相色谱法使我们能够在显微切割样本中进行这些测量，并同时测定单胺类代谢产物。多巴胺水平在新纹状体中最高，在EnPi和CIN中适中，在SSC、VIS和海马体中非常低。去甲肾上腺素的分布更为均匀，尽管在新纹状体、海马体和EnPi中测量到较高浓度。5-羟色胺含量最高的是EnPi，而在其他区域发现的浓度适中。神经递质与其代谢产物之间的比率被用作周转率指标，表明单胺系统的终末场所在新纹状体、海马体和皮质亚区中是异质性的。
