• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在慢性再生障碍性贫血患者中，骨髓来源的间充质干细胞通过影响 Notch/RBP-J/FOXP3/RORγt 通路来调节 Treg/Th17 平衡。

In patients with chronic aplastic anemia, bone marrow-derived MSCs regulate the Treg/Th17 balance by influencing the Notch/RBP-J/FOXP3/RORγt pathway.

机构信息

Department of Hematology, General Hospital of Guangzhou Military Command of Chinese PLA; Guangzhou, Guangdong 510010, P.R. China.

Department of Emergency, The First Affiliated Hospital of Guangzhou University of Chinese Medicine; Guangzhou, Guangdong 510405, P.R. China.

出版信息

Sci Rep. 2017 Feb 14;7:42488. doi: 10.1038/srep42488.

DOI:10.1038/srep42488
PMID:28195151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5307358/
Abstract

The standard treatment for aplastic anemia (AA) in young patients is a matched sibling hematopoietic stem cell transplant. Transfusion of a chronic AA patient with allogeneic bone marrow-derived mesenchymal stromal cells (BMMSCs) is currently being developed as a cell-based therapy, and the safety and efficacy of such transfusions are being continuously improved. Nevertheless, the mechanisms by which BMMSCs exert their therapeutic effects remain to be elucidated. In this study, mesenchymal stromal cells (MSCs) obtained from bone marrow donors were concentrated and intravenously injected into 15 chronic AA patients who had been refractory to prior immunosuppressive therapy. We showed that BMMSCs modulate the levels of Th1, Th2, Th17 and Treg cells, as well as their related cytokines in chronic AA patients. Furthermore, the percentages of Th1 and Th17 cells among the H-MSCs decreased significantly, while the percentage Treg cells increased. The Notch/RBP-J/FOXP3/RORγt pathway was involved in modulating the Treg/Th17 balance after MSCs were transfused in vitro. Additionally, the role played by transfused MSCs in regulating the Treg/Th17 balance via the Notch/RBP-J/FOXP3/RORγt pathway was further confirmed in an AA mouse model. In summary, in humans with chronic AA, BMMSCs regulate the Treg/Th17 balance by affecting the Notch/RBP-J/FOXP3/RORγt pathway.

摘要

再生障碍性贫血（AA）患者的标准治疗方法是接受匹配的同胞造血干细胞移植。目前正在开发用异体骨髓来源的间充质基质细胞（BMMSCs）输注治疗慢性 AA 患者，作为一种细胞治疗方法，这种输注的安全性和有效性正在不断提高。然而，BMMSCs 发挥治疗作用的机制仍有待阐明。在这项研究中，从骨髓供者中浓缩获得间充质基质细胞（MSCs），并静脉内注射到 15 例先前对免疫抑制治疗有抗药性的慢性 AA 患者中。我们表明，BMMSCs 调节慢性 AA 患者 Th1、Th2、Th17 和 Treg 细胞及其相关细胞因子的水平。此外，H-MSCs 中 Th1 和 Th17 细胞的百分比显著下降，而 Treg 细胞的百分比增加。在体外转输 MSCs 后，Notch/RBP-J/FOXP3/RORγt 通路参与调节 Treg/Th17 平衡。此外，在 AA 小鼠模型中进一步证实，转输的 MSCs 通过 Notch/RBP-J/FOXP3/RORγt 通路在调节 Treg/Th17 平衡中发挥作用。综上所述，在慢性 AA 患者中，BMMSCs 通过影响 Notch/RBP-J/FOXP3/RORγt 通路来调节 Treg/Th17 平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/026e8b1390b9/srep42488-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/4a5e9c47a5d5/srep42488-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/3520f8d32559/srep42488-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/2f653c1a2980/srep42488-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/327e4ebb8e29/srep42488-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/026e8b1390b9/srep42488-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/4a5e9c47a5d5/srep42488-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/3520f8d32559/srep42488-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/2f653c1a2980/srep42488-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/327e4ebb8e29/srep42488-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6315/5307358/026e8b1390b9/srep42488-f5.jpg

相似文献

1
In patients with chronic aplastic anemia, bone marrow-derived MSCs regulate the Treg/Th17 balance by influencing the Notch/RBP-J/FOXP3/RORγt pathway.在慢性再生障碍性贫血患者中，骨髓来源的间充质干细胞通过影响 Notch/RBP-J/FOXP3/RORγt 通路来调节 Treg/Th17 平衡。
Sci Rep. 2017 Feb 14;7:42488. doi: 10.1038/srep42488.
2
Exosomal sphingosine 1-phosphate secreted by mesenchymal stem cells regulated Treg/Th17 balance in aplastic anemia.骨髓增生异常综合征中间充质干细胞分泌的外泌体神经酰胺 1-磷酸调节调节性 T 细胞/辅助性 T17 细胞平衡。
IUBMB Life. 2019 Sep;71(9):1284-1292. doi: 10.1002/iub.2035. Epub 2019 Mar 19.
3
Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance.胎盘间充质干细胞通过调节 Th17/Treg 平衡改善哮喘大鼠的气道高反应性和炎症。
Mol Med Rep. 2017 Dec;16(6):8137-8145. doi: 10.3892/mmr.2017.7605. Epub 2017 Sep 25.
4
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.间充质干细胞在Th1和Th17细胞分化过程中产生CD4+CD25+Foxp3+调节性T细胞群体。
Stem Cell Res Ther. 2013 Jun 4;4(3):65. doi: 10.1186/scrt216.
5
Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia.Notch 信号失活可逆转免疫性血小板减少症患者细胞中的 Th17/Treg 失衡。
Lab Invest. 2015 Feb;95(2):157-67. doi: 10.1038/labinvest.2014.142. Epub 2014 Dec 8.
6
RORγt expression in T promotes systemic lupus erythematosus via IL-17 secretion, alteration of T phenotype and suppression of Th2 responses.T细胞中RORγt的表达通过白细胞介素-17分泌、T细胞表型改变和Th2反应抑制促进系统性红斑狼疮。
Clin Exp Immunol. 2017 Apr;188(1):63-78. doi: 10.1111/cei.12905. Epub 2017 Jan 5.
7
Salidroside affects the Th17/Treg cell balance in aplastic anemia via the STAT3/HIF-1α/RORγt pathway.红景天苷通过 STAT3/HIF-1α/RORγt 通路影响再生障碍性贫血中的 Th17/Treg 细胞平衡。
Redox Rep. 2023 Dec;28(1):2225868. doi: 10.1080/13510002.2023.2225868.
8
The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus.间充质干细胞对人类系统性红斑狼疮中Treg/Th17平衡的调节作用
Cell Mol Immunol. 2017 May;14(5):423-431. doi: 10.1038/cmi.2015.89. Epub 2015 Oct 5.
9
Shenghua Decoction reduces uterine bleeding and regulates T-cell paradigm in human deciduas of RU486 medical abortion.生化汤减少 RU486 药物流产人蜕膜组织中 T 细胞范式的出血。
J Ethnopharmacol. 2013 Dec 12;150(3):907-17. doi: 10.1016/j.jep.2013.09.033. Epub 2013 Oct 17.
10
Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation.Notch信号通路通过抑制Foxp3表达和调节性T细胞分化促进变应性鼻炎的发展。
Int Arch Allergy Immunol. 2019;178(1):33-44. doi: 10.1159/000493328. Epub 2018 Nov 2.

引用本文的文献

1
Origins of T-cell-mediated autoimmunity in acquired aplastic anaemia.获得性再生障碍性贫血中T细胞介导的自身免疫的起源。
Br J Haematol. 2025 Apr;206(4):1035-1053. doi: 10.1111/bjh.19993. Epub 2025 Jan 21.
2
Exploring the mechanism by which improves haematopoietic function in aplastic anaemia.探讨 改善再生障碍性贫血造血功能的机制。
Aging (Albany NY). 2024 Jun 26;16(15):11535-11552. doi: 10.18632/aging.205971.
3
Agrimonolide mitigated DSS-induced colitis by modulating the balance between Treg and Th17 cells through the suppression of the Notch and JAK2/STAT3 signaling pathways.

本文引用的文献

1
Emerging role of microRNA-21 in cancer.微小RNA-21在癌症中的新兴作用。
Biomed Rep. 2016 Oct;5(4):395-402. doi: 10.3892/br.2016.747. Epub 2016 Aug 26.
2
Understanding the Regulatory Roles of Natural Killer T Cells in Rheumatoid Arthritis: T Helper Cell Differentiation Dependent or Independent?了解自然杀伤T细胞在类风湿性关节炎中的调节作用：依赖或独立于辅助性T细胞分化？
Scand J Immunol. 2016 Oct;84(4):197-203. doi: 10.1111/sji.12460.
3
Haploidentical Stem Cell Transplantation in Adult Haematological Malignancies.成人血液系统恶性肿瘤中的单倍体相合干细胞移植
龙牙草内酯通过抑制Notch和JAK2/STAT3信号通路调节Treg和Th17细胞之间的平衡，从而减轻DSS诱导的结肠炎。
Heliyon. 2024 Jun 27;10(13):e33803. doi: 10.1016/j.heliyon.2024.e33803. eCollection 2024 Jul 15.
4
Increased Expression of NOTCH-1 and T Helper Cell Transcription Factors in Patients with Acquired Aplastic Anemia.NOTCH-1 和辅助性 T 细胞转录因子在获得性再生障碍性贫血患者中的表达增加。
Iran Biomed J. 2023 Nov 1;27(6):357-65. doi: 10.61186/ibj.3754. Epub 2022 Jul 31.
5
Resveratrol inhibits AhR/Notch axis and reverses Th17/Treg imbalance in purpura by activating Foxp3.白藜芦醇通过激活叉头框蛋白3（Foxp3）抑制芳烃受体（AhR）/Notch轴，并逆转紫癜中辅助性T细胞17（Th17）/调节性T细胞（Treg）失衡。
Toxicol Res (Camb). 2023 Apr 20;12(3):381-391. doi: 10.1093/toxres/tfad021. eCollection 2023 Jun.
6
Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia.抗环氧化酶 2 自身抗体是免疫性再生障碍性贫血的一种新型生物标志物。
Leukemia. 2022 Sep;36(9):2317-2327. doi: 10.1038/s41375-022-01654-6. Epub 2022 Aug 5.
7
The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy.IL-33/ST2 信号在肿瘤微环境和 Treg 免疫治疗中的作用。
Exp Biol Med (Maywood). 2022 Oct;247(20):1810-1818. doi: 10.1177/15353702221102094. Epub 2022 Jun 22.
8
Mechanism of Xiaoying Daotan decoction in treating Hashimoto's thyroiditis based on the Notch/Treg/Th17 pathway.基于Notch/Treg/Th17通路探讨消瘿化痰汤治疗桥本甲状腺炎的机制
Ann Transl Med. 2021 Dec;9(24):1760. doi: 10.21037/atm-21-6253.
9
Exosomes derived from mesenchymal stem cells regulate Treg/Th17 balance in aplastic anemia by transferring miR-23a-3p.间充质干细胞来源的外泌体通过转移 miR-23a-3p 调节再生障碍性贫血中的 Treg/Th17 平衡。
Clin Exp Med. 2021 Aug;21(3):429-437. doi: 10.1007/s10238-021-00701-3. Epub 2021 Mar 29.
10
Mesenchymal Stem Cells in Aplastic Anemia and Myelodysplastic Syndromes: The "Seed and Soil" Crosstalk.骨髓增生异常综合征和再生障碍性贫血中的间充质干细胞：“种子与土壤”的对话。
Int J Mol Sci. 2020 Jul 30;21(15):5438. doi: 10.3390/ijms21155438.
Adv Hematol. 2016;2016:3905907. doi: 10.1155/2016/3905907. Epub 2016 May 30.
4
The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation.间充质基质细胞在造血干细胞移植中的临床应用。
J Hematol Oncol. 2016 May 18;9(1):46. doi: 10.1186/s13045-016-0276-z.
5
T cell receptor signalling in the control of regulatory T cell differentiation and function.T细胞受体信号传导在调节性T细胞分化和功能的控制中
Nat Rev Immunol. 2016 Apr;16(4):220-33. doi: 10.1038/nri.2016.26.
6
[Acquired aplastic anemia].[获得性再生障碍性贫血]
Rinsho Ketsueki. 2016 Feb;57(2):91-7. doi: 10.11406/rinketsu.57.91.
7
The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome.调节性T细胞/辅助性T细胞17轴：由肠道微生物群调节的动态平衡
Front Immunol. 2015 Dec 17;6:639. doi: 10.3389/fimmu.2015.00639. eCollection 2015.
8
Intravenous infusion of allogeneic mesenchymal stromal cells in refractory or relapsed aplastic anemia.难治性或复发性再生障碍性贫血患者的异基因间充质基质细胞静脉输注
Cytotherapy. 2015 Dec;17(12):1696-705. doi: 10.1016/j.jcyt.2015.09.006.
9
The diagnosis and treatment of aplastic anemia: a review.再生障碍性贫血的诊断与治疗：综述
Int J Hematol. 2015 Jun;101(6):527-35. doi: 10.1007/s12185-015-1787-z. Epub 2015 Apr 3.
10
Characterization of bone marrow mesenchymal stromal cells in aplastic anaemia.再生障碍性贫血中骨髓间充质基质细胞的特征。
Br J Haematol. 2015 Jun;169(6):804-13. doi: 10.1111/bjh.13364. Epub 2015 Mar 29.