微小RNA-21在癌症中的新兴作用。
Emerging role of microRNA-21 in cancer.
作者信息
Feng Yin-Hsun, Tsao Chao-Jung
机构信息
Division of Hematology and Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan 71004, Taiwan, R.O.C.; Department of Nursing, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 71703, Taiwan, R.O.C.
Department of Hematology and Oncology, Chi-Mei Medical Center, Tainan 73657, Taiwan, R.O.C.
出版信息
Biomed Rep. 2016 Oct;5(4):395-402. doi: 10.3892/br.2016.747. Epub 2016 Aug 26.
Abstract
MicroRNAs (miRs) are a class of single-stranded RNA molecules of 15-27 nucleotides in length that regulate gene expression at the post-translational level. miR-21 is one of the earliest identified cancer-promoting 'oncomiRs', targeting numerous tumor suppressor genes associated with proliferation, apoptosis and invasion. The regulation of miR-21 and its role in carcinogenesis have been extensively investigated. Recent studies have focused on the diagnostic and prognostic value of miR-21 as well as its implication in the drug resistance of human malignancies. The further use of miR-21 as a biomarker and target for cancer treatments is likely to improve the outcome for patients with cancer. The present review highlights recent findings associated with the importance of miR-21 in hematological and non-hematological malignancies.
摘要
微小RNA（miR）是一类长度为15 - 27个核苷酸的单链RNA分子，可在翻译后水平调节基因表达。miR - 21是最早被鉴定出的促癌“致癌miR”之一，靶向许多与增殖、凋亡和侵袭相关的肿瘤抑制基因。miR - 21的调控及其在致癌过程中的作用已得到广泛研究。最近的研究集中在miR - 21的诊断和预后价值及其在人类恶性肿瘤耐药性中的意义。进一步将miR - 21用作癌症治疗的生物标志物和靶点可能会改善癌症患者的预后。本综述重点介绍了与miR - 21在血液系统和非血液系统恶性肿瘤中的重要性相关的最新研究结果。
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Oncotarget. 2016 Apr 19;7(16):22566-78. doi: 10.18632/oncotarget.8124.
2
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Cancer Med. 2016 Apr;5(4):693-702. doi: 10.1002/cam4.626. Epub 2016 Feb 10.
3
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8
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9
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