Wu C W, Wang S R, Chang T J, Lin E C, Chang K L, Huang M H, Lui W Y, P'eng F K, Chi C W
Department of Surgery, Veterans General Hospital, Taiwan, ROC.
Cancer. 1989 Dec 15;64(12):2552-6. doi: 10.1002/1097-0142(19891215)64:12<2552::aid-cncr2820641224>3.0.co;2-y.
The content of glucocorticoid receptor (GR) and arginase in human gastric cancer and the corresponding normal gastric mucosal tissues was determined. Among the 25 patients studied, the GR content in gastric cancer tissues was 33.2 +/- 10.2 fmol/mg protein versus 7.6 +/- 3.4 fmol/mg protein in gastric mucosal tissues. This difference is statistically significant (P less than 0.005). Of the 25 paired samples, 19 cancer tissues contained GR, whereas only seven of the normal mucosal tissues had GR. The level of arginase in gastric cancer tissues in 19 patients was assayed, it was 26.6 +/- 4.2 ng/mg protein which is also significantly higher than that in normal gastric mucosal tissues (13.5 +/- 1.8 ng/mg protein) (P less than 0.005). Since glucocorticoids and arginase are potent immune suppressive agents, the increased level of GR and arginase in gastric cancer tissue suggest that these glucocorticoid-related factors in gastric cancer tissue may play a partial role in regulating cellular immunity.
测定了人胃癌组织及相应正常胃黏膜组织中糖皮质激素受体（GR）和精氨酸酶的含量。在所研究的25例患者中，胃癌组织中GR含量为33.2±10.2 fmol/mg蛋白，而胃黏膜组织中为7.6±3.4 fmol/mg蛋白。这种差异具有统计学意义（P＜0.005）。在25对配对样本中，19例癌组织含有GR，而正常黏膜组织中仅有7例含有GR。检测了19例患者胃癌组织中的精氨酸酶水平，为26.6±4.2 ng/mg蛋白，也显著高于正常胃黏膜组织（13.5±1.8 ng/mg蛋白）（P＜0.005）。由于糖皮质激素和精氨酸酶是强效免疫抑制剂，胃癌组织中GR和精氨酸酶水平的升高表明，这些与糖皮质激素相关的因子可能在调节细胞免疫中发挥部分作用。
