El Hayderi L, Rübben A, Nikkels A F
Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.
Department of Dermatology, RWTH Aachen, Aachen, Germany.
Hautarzt. 2017 Dec;68(Suppl 1):1-5. doi: 10.1007/s00105-016-3919-7.
This review on herpes simplex virus type I and type II (HSV‑I, HSV‑II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV‑I infection; HSV-related folliculitis; verrucous HSV‑I and HSV‑II lesions; the role of recurrent HSV‑I infection in burning mouth syndrome; HSV‑I and HSV‑II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV‑I or HSV‑II are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. New anti-HSV‑I and anti-HSV‑II agents include amenavir, pritelivir, brincidofovir, valomaciclovir, and FV-100. Therapeutic or preventive vaccination against HSV‑I and HSV‑II infections still remains a highly desirable treatment aim, which, unfortunately, has no clinically relevant applications to date.
这篇关于单纯疱疹病毒I型和II型（HSV-I、HSV-II）的综述总结了原发性和复发性口周及生殖器疱疹在临床表现和治疗干预方面的最新进展，以及疫苗接种问题的相关进展。在临床表现方面，讨论了化脓性肉芽肿与慢性HSV-I感染之间的关系；HSV相关的毛囊炎；疣状HSV-I和HSV-II病变；复发性HSV-I感染在灼口综合征中的作用；乳晕区的HSV-I和HSV-II感染；带状疱疹样HSV；“刀切征”；以及HSV-I或HSV-II对原有皮肤病的优先定植和感染。将原发性和复发性口周及生殖器疱疹的常用抗病毒治疗方案与短期和一日治疗方案进行了比较。新的抗HSV-I和抗HSV-II药物包括阿美那韦、普瑞替韦、布林西多福韦、伐洛韦和FV-100。针对HSV-I和HSV-II感染的治疗性或预防性疫苗接种仍然是一个非常理想的治疗目标，不幸的是，迄今为止尚无临床相关应用。
