Chu D C, Penney J B, Young A B
Neurology. 1987 Sep;37(9):1454-9. doi: 10.1212/wnl.37.9.1454.
GABAB and GABAA binding sites were evaluated by quantitative autoradiography of 3H-GABA binding in superior frontal gyrus of persons who died with dementia of the Alzheimer's type (DAT) and of age-matched normal controls. Scatchard analysis and competition studies disclosed 48 to 68% and 25% decrements in receptor density (Bmax) for GABAB and GABAA receptors, respectively, in layers II, III, and V of DAT frontal cortex as compared with controls. No significant difference in affinity (KD) for either GABAA or GABAB receptors was found. Our data may reflect multisystem pathologic involvement in DAT neocortex.
通过对死于阿尔茨海默病型痴呆（DAT）的患者及年龄匹配的正常对照者的额上回进行³H-GABA结合的定量放射自显影，评估了GABAB和GABAA结合位点。Scatchard分析和竞争研究显示，与对照组相比，DAT额叶皮质的II、III和V层中，GABAB和GABAA受体的受体密度（Bmax）分别降低了48%至68%和25%。未发现GABAA或GABAB受体的亲和力（KD）有显著差异。我们的数据可能反映了DAT新皮质的多系统病理累及情况。
