Chu D C, Penney J B, Young A B
Department of Neurology, University of Michigan, Ann Arbor 48109.
Neurosci Lett. 1987 Dec 4;82(3):246-52. doi: 10.1016/0304-3940(87)90264-3.
GABAB and GABAA receptors were examined by quantitative [3H]GABA autoradiography in postmortem human hippocampus from 6 histopathologically verified cases of dementia of the Alzheimer type (DAT) and 6 normal controls. Significant decrements in the Bmax for both types of GABA receptors were observed in DAT hippocampus as compared to normal controls. No significant differences in Kd values were revealed. As compared to controls, DAT hippocampus exhibited fewer GABAB receptors in stratum moleculare of the dentate gyrus, stratum lacunosum-moleculare and stratum pyramidale of CA1. Significant loss of GABAA receptors in DAT hippocampus was also observed in the CA1 pyramidal cell region. These changes could not be correlated with differences in age nor in postmortem delay between the two groups. These findings may reflect the neuronal pathologies in CA1 region, in dentate gyrus, and in projections from the entorhinal cortex which are associated with the memory impairment in DAT.
通过定量[3H]GABA放射自显影技术，对6例经组织病理学证实的阿尔茨海默型痴呆（DAT）患者和6例正常对照者的尸检后人类海马体中的GABAB和GABAA受体进行了检测。与正常对照相比，在DAT海马体中观察到两种类型的GABA受体的Bmax均显著降低。未发现Kd值有显著差异。与对照组相比，DAT海马体在齿状回分子层、CA1的腔隙分子层和锥体细胞层中显示出较少的GABAB受体。在CA1锥体细胞区域也观察到DAT海马体中GABAA受体的显著丢失。这些变化与两组之间的年龄差异或死后延迟无关。这些发现可能反映了CA1区域、齿状回以及内嗅皮质投射中的神经元病变，这些病变与DAT中的记忆损害有关。
