Haleem Darakhshan Jabeen, Sheikh Shehnaz, Fawad Asher, Haleem Muhammad A
Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi, 75270, Pakistan.
Department of Biochemistry, Liaquat National Hospital & Medical College, Karachi, Pakistan.
Metab Brain Dis. 2017 Jun;32(3):757-764. doi: 10.1007/s11011-017-9964-9. Epub 2017 Feb 15.
A large number of diabetes patients suffer from major depression and are at high risk of mortality. In view of a role of leptin in diabetes, depression and energy homeostasis, the present study concerns circulating levels of leptin in different BMI groups of un-depressed and depressed diabetes patients. Six hundred thirty male and female patients with a primary diagnosis of diabetes were grouped according to BMI and with or without clinical symptoms of depression. Age matched healthy, normal weight male and female volunteers without clinical symptoms of depression or diabetes were taken as controls. Blood samples were obtained after an overnight fast of 12 h. Serum was stored for the determination of leptin and glucose. We found that there were more female than male diabetes patients with comorbid depression. Fasting leptin was higher in normal weight non-diabetes women than men; but comparable in normal weight men and women diabetes patients. Fasting glucose levels were higher in diabetes than non diabetes groups; values were comparable in men and women. Depression was associated with a decrease and increase in leptin respectively in normal-overweight and obese men and women diabetes patients. Glucose levels were also higher in obese depressed than un-depressed diabetes patients. The results suggested that the female gender is at greater risk to comorbid diabetes with depression. Adipo-insular axis plays an important role in diabetes, associated depression and in the greater risk of the female gender to comorbid diabetes with depression.
大量糖尿病患者患有重度抑郁症，且死亡风险很高。鉴于瘦素在糖尿病、抑郁症和能量稳态中的作用，本研究关注未患抑郁症和患抑郁症的糖尿病患者不同体重指数（BMI）组中的循环瘦素水平。630例初步诊断为糖尿病的男性和女性患者根据BMI以及有无抑郁症临床症状进行分组。选取年龄匹配、无抑郁症或糖尿病临床症状的健康、体重正常的男性和女性志愿者作为对照。在禁食12小时后采集血样。血清储存起来用于测定瘦素和葡萄糖。我们发现，合并抑郁症的糖尿病女性患者比男性患者更多。正常体重的非糖尿病女性的空腹瘦素水平高于男性；但正常体重的男性和女性糖尿病患者的空腹瘦素水平相当。糖尿病组的空腹血糖水平高于非糖尿病组；男性和女性的数值相当。在正常体重至超重以及肥胖的男性和女性糖尿病患者中，抑郁症分别与瘦素水平降低和升高相关。肥胖的抑郁症糖尿病患者的血糖水平也高于未患抑郁症的糖尿病患者。结果表明，女性患糖尿病合并抑郁症的风险更高。脂肪-胰岛轴在糖尿病、相关抑郁症以及女性患糖尿病合并抑郁症的更高风险中起重要作用。
