Robakis Thalia K, Aasly Linn, Williams Katherine Ellie, Clark Claire, Rasgon Natalie
Stanford University, Department of Psychiatry and Behavioral Sciences.
Palo Alto University, Program in Clinical Psychology.
Curr Behav Neurosci Rep. 2017 Dec;4(4):369-383. doi: 10.1007/s40473-017-0131-8. Epub 2017 Oct 28.
Inflammation, the body's response to harmful external agents, has long been found to be associated with depressive symptoms. The relationship between inflammation and depression is well established in the general population of people with depression, but is less so among perinatal women. Depression in the perinatal period is a common disorder, however available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. In this review we explore the available support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy.
炎症是身体对有害外部因素的反应，长期以来人们发现它与抑郁症状有关。炎症与抑郁症之间的关系在抑郁症患者的普通人群中已得到充分证实，但在围产期女性中则不太明确。围产期抑郁症是一种常见疾病，然而现有数据并未表明存在与围产期抑郁症相关的特定炎症表现。我们认为围产期抑郁症可能是一种异质性结构，并且在妊娠的其他炎症性疾病背景下，炎症可能与之相关。在本综述中，我们探讨了以下假设的现有依据：与抑郁症相关的炎症可能是妊娠期糖尿病（一种已知的妊娠炎症性疾病）发生的促发因素。
