小泛素样修饰蛋白对细胞过程的调控：研究不足的主题

Regulation of Cellular Processes by SUMO: Understudied Topics.

作者信息

Enserink Jorrit M

机构信息

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital and University of Oslo, Ullernchausseen 70, 0379, Oslo, Norway.

出版信息

Adv Exp Med Biol. 2017;963:89-97. doi: 10.1007/978-3-319-50044-7_5.

DOI:10.1007/978-3-319-50044-7_5

PMID:28197907

Abstract

SUMO plays a multiple role in maintenance of cellular homeostasis, both under normal conditions and under cell stress . Considerable effort has been devoted to unraveling the functions of SUMO in regulation of transcription and preservation of genome stability. However, it is clear from high-throughput SUMO proteome studies that SUMO likely regulates many more cellular processes. The function of SUMO in these processes has hardly been explored. This review will focus on the emerging function of SUMO in regulation of several of these processes.

摘要

SUMO在维持细胞内稳态方面发挥着多重作用，无论是在正常条件下还是在细胞应激状态下。人们已经投入了大量精力来揭示SUMO在转录调控和基因组稳定性维持中的功能。然而，从高通量SUMO蛋白质组学研究中可以清楚地看出，SUMO可能调控更多的细胞过程。SUMO在这些过程中的功能几乎尚未得到探索。本综述将聚焦于SUMO在调控其中一些过程中新兴的功能。