溃疡性结肠炎患者的结膜印迹细胞学与干眼：一项初步研究
Conjunctival Impression Cytology and Dry Eye in Patients With Ulcerative Colitis: A Pilot Study.
作者信息
Oltulu Pembe, Oltulu Refik, Asil Mehmet, Satirtav Gunhal, Mirza Enver
机构信息
Departments of Pathology (P.O.), Ophthalmology (R.O., G.S., E.M.), and Gastroenterology (M.A.), Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
出版信息
Eye Contact Lens. 2018 Sep;44 Suppl 1:S190-S193. doi: 10.1097/ICL.0000000000000380.
PURPOSE
The aim of this study was to compare signs of dry eye between ulcerative colitis (UC) patients and healthy subjects.
METHODS
Fifteen patients with UC (group 1) and 15 healthy subjects (group 2) were enrolled in this study. Tear volume measurement, Schirmer-I test with no anesthetic, tear break-up time, and conjunctival impression cytology (CIC) were evaluated in both groups.
RESULTS
Patients with UC showed lower tear volumes when compared with healthy subjects (P<0.05). There was a statistically significant difference in distribution of CIC grades between groups 1 and 2 (P<0.05). Tear break-up time and Schirmer-I measurements were significantly lower in group 1 compared with group 2 (P<0.05).
CONCLUSIONS
The results of this study indicate that UC is associated with demonstrable disturbances in tear function and conjunctival cytology.
目的
本研究旨在比较溃疡性结肠炎（UC）患者与健康受试者的干眼体征。
方法
本研究纳入了15例UC患者（第1组）和15名健康受试者（第2组）。对两组均进行泪液量测量、无麻醉下的Schirmer - I试验、泪膜破裂时间和结膜印迹细胞学检查（CIC）。
结果
与健康受试者相比，UC患者的泪液量较低（P<0.05）。第1组和第2组之间CIC分级分布存在统计学显著差异（P<0.05）。与第2组相比，第1组的泪膜破裂时间和Schirmer - I测量值显著更低（P<0.05）。
结论
本研究结果表明，UC与泪液功能和结膜细胞学的明显紊乱有关。
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