Ebefors Kerstin, Nyström Jenny
Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Curr Opin Nephrol Hypertens. 2017 May;26(3):143-147. doi: 10.1097/MNH.0000000000000310.
The kidney is a highly complex organ and renal function depends on many factors, both extrinsic to the kidney and intrinsic. The kidney responds both to systemic hormonal and neuronal signals and to autocrine and paracrine factors produced within the renal tissue. Recently, there has been an increased emphasis on crosstalk in and between different compartments in the kidney.
Crosstalk in the kidney between different cellular compartments has added new and important understanding of renal function and the development of kidney disease.
Most of the literature cited concern glomerular crosstalk but also tubular and interstitial crosstalk are being reviewed. Mechanistic insight into the communication between the cells may help us find new targets for treating kidney disease.
肾脏是一个高度复杂的器官，肾功能取决于许多因素，包括肾脏外部和内部的因素。肾脏既对全身激素和神经信号作出反应，也对肾组织内产生的自分泌和旁分泌因子作出反应。最近，人们越来越重视肾脏不同区域内和之间的相互作用。
肾脏不同细胞区域之间的相互作用为肾功能和肾脏疾病的发展带来了新的重要认识。
引用的大多数文献涉及肾小球相互作用，但肾小管和间质相互作用也在被综述。对细胞间通讯的机制性洞察可能有助于我们找到治疗肾脏疾病的新靶点。
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