Swartzwelder H S, Tilson H A, McLamb R L, Wilson W A
Psychopharmacology (Berl). 1987;92(3):398-401. doi: 10.1007/BF00210851.
Baclofen (Lioresal, Ciba-Geigy) is an analog of the inhibitory neurotransmitter GABA and is used clinically to control spasticity. Recent studies have demonstrated that this compound produces a marked inhibition of synaptically evoked responses in area CA3 of the hippocampal slice, suggesting that this drug could influence behavior mediated by the limbic system. In the present study, male rats of the Fischer-344 strain were trained on a one-trial passive avoidance task and tested for retention 1 week later. After the training trial, separate groups of rats received either 5 or 10 mg/kg/4 ml IP of baclofen or the distilled H2O vehicle immediately, 10 min, or 60 min after training. One week later, the rats that received baclofen immediately after training reentered the test chamber with a significantly higher frequency than controls, although no differences in vacillatory responses were observed between groups. Similar effects were observed following posttrial administration of chlordiazepoxide. In a separate experiment rats were tested for locomotor activity after receiving the same doses of baclofen. Although baclofen decreased activity during a 30-min period after dosing, rats exposed to baclofen showed no significant change in activity relative to controls 1 week later. These data are consistent with the interpretation that baclofen may interfere with memory consolidation or retention.
巴氯芬（力奥来素，汽巴 - 嘉基公司）是抑制性神经递质γ-氨基丁酸的类似物，临床上用于控制痉挛。最近的研究表明，该化合物对海马切片CA3区的突触诱发反应有显著抑制作用，这表明这种药物可能会影响边缘系统介导的行为。在本研究中，对Fischer - 344品系的雄性大鼠进行单次被动回避任务训练，并在1周后测试记忆保持情况。训练试验后，将大鼠分成不同组，分别在训练后立即、10分钟或60分钟腹腔注射5或10毫克/千克/4毫升的巴氯芬或蒸馏水载体。1周后，训练后立即接受巴氯芬注射的大鼠重新进入测试室的频率显著高于对照组，尽管各组之间在犹豫反应方面未观察到差异。给予氯氮卓后也观察到类似效果。在另一个实验中，给大鼠注射相同剂量的巴氯芬后测试其运动活性。尽管给药后30分钟内巴氯芬降低了活性，但1周后，接受巴氯芬的大鼠与对照组相比，活性没有显著变化。这些数据与巴氯芬可能干扰记忆巩固或保持的解释一致。
