Emergency Department, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No 301, Mid Yangchang Road, Shanghai, China.
Emergency Department, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No 301, Mid Yangchang Road, Shanghai, China,
Front Biosci (Landmark Ed). 2017 Mar 1;22(8):1344-1354. doi: 10.2741/4547.
Sepsis, an under-recognized health problem, is a major cause of death. More than 750,000 individuals develop sepsis annually, of whom 215,000 die of the disease. Clinical and experimental evidence indicates that patients with sepsis present with rapid impairment of immune function; biomarkers are therefore needed to enable early detection of this condition. Reduced monocyte human leukocyte antigen-DR (HLA-DR) expression, which is measured by flow cytometry, is currently the most popular biomarker for sepsis detection. In addition, the determination of HLA-DR expression provides valuable information in terms of predicting mortality and risk of secondary infections. HLA-DR levels have been shown to be inversely correlated with the severity of sepsis and immune dysfunction. In this review, we provide an overview of the association between sepsis and HLA-DR expression in terms of the predictive value of the latter in sepsis.
脓毒症是一个未被充分认识的健康问题，是主要死亡原因之一。每年有超过 75 万人发生脓毒症，其中 21.5 万人死于该病。临床和实验证据表明，脓毒症患者的免疫功能迅速受损；因此需要生物标志物来实现对这种情况的早期检测。通过流式细胞术测量的单核细胞人类白细胞抗原-DR（HLA-DR）表达降低，是目前脓毒症检测最常用的生物标志物。此外，HLA-DR 表达的测定在预测死亡率和二次感染风险方面提供了有价值的信息。HLA-DR 水平与脓毒症的严重程度和免疫功能障碍呈负相关。在这篇综述中，我们根据后者在脓毒症中的预测价值，概述了脓毒症与 HLA-DR 表达之间的关联。
