Department of Medical Laboratory, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China.
Front Immunol. 2024 Aug 15;15:1449986. doi: 10.3389/fimmu.2024.1449986. eCollection 2024.
Sepsis is defined as a life-threatening organ dysfunction syndrome caused by dysregulated host response to infection, characterized by a systemic inflammatory response to infection. The use of antibiotics, fluid resuscitation, and organ support therapy has limited prognostic benefit in patients with sepsis, and its incidence is not diminishing, which is attracting increased attention in medicine. Sepsis remains one of the most debilitating and expensive illnesses. One of the main reasons of septic mortality is now understood to be disruption of immune homeostasis. Immunotherapy is revolutionizing the treatment of illnesses in which dysregulated immune responses play a significant role. This "trained immunity", which is a potent defense against infection regardless of the type of bacteria, fungus, or virus, is attributed to the discovery that the innate immune cells possess immune memory via metabolic and epigenetic reprogramming. Here we reviewed the immunotherapy of innate immune cells in sepsis, the features of trained immunity, and the relationship between trained immunity and sepsis.
脓毒症定义为感染导致宿主反应失调引起的危及生命的器官功能障碍综合征，其特征是全身性炎症反应。抗生素、液体复苏和器官支持治疗的使用对脓毒症患者的预后获益有限，其发病率并未降低，这在医学领域引起了越来越多的关注。脓毒症仍然是最具破坏性和最昂贵的疾病之一。现在人们已经认识到，脓毒症死亡的主要原因之一是免疫稳态的破坏。免疫疗法正在彻底改变治疗那些免疫反应失调发挥重要作用的疾病。这种“训练有素的免疫”是一种针对感染的强大防御机制，无论细菌、真菌还是病毒，都可以通过代谢和表观遗传重编程使先天免疫细胞具有免疫记忆。在这里，我们综述了脓毒症中先天免疫细胞的免疫疗法、训练有素的免疫的特征，以及训练有素的免疫与脓毒症之间的关系。
