Tanabe Kento, Itoh Motoyuki, Tonoki Ayako
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan.
Cell Rep. 2017 Feb 14;18(7):1598-1605. doi: 10.1016/j.celrep.2017.01.053.
Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that intermediate-term memory (ITM), but not short-term memory (STM), in Drosophila aversive olfactory memory requires transient IIS during adulthood. The expression of Drosophila insulin-like peptide 3 (Dilp3) in insulin-producing cells and insulin receptor function in the fat body are essential for ITM. Although the expression of dilp3 decreases with aging, which is unique among dilp genes, the transient expression of dilp3 in aged flies enhances ITM. These findings indicate that ITM is systemically regulated by communication between insulin-producing cells and fat body and that age-dependent changes in IIS contribute to age-related memory impairment.
胰岛素及胰岛素样生长因子信号通路（IIS）在发育、生长、代谢稳态、衰老的调节过程中发挥着重要作用，在诸如学习和记忆等脑功能方面也同样如此。IIS在学习和记忆中的时空作用及其对年龄依赖性记忆损伤的影响仍不清楚。在此，我们报告称，果蝇厌恶嗅觉记忆中的中期记忆（ITM）而非短期记忆（STM），在成年期需要短暂的IIS。果蝇胰岛素样肽3（Dilp3）在胰岛素生成细胞中的表达以及脂肪体中的胰岛素受体功能对ITM至关重要。尽管dilp3的表达会随着衰老而降低，这在dilp基因中是独特的，但在老龄果蝇中短暂表达dilp3可增强ITM。这些发现表明，ITM受到胰岛素生成细胞与脂肪体之间通讯的系统性调节，并且IIS中与年龄相关的变化导致了与年龄相关的记忆损伤。
