Wechsler J G, Wenzel H, Swobodnik W, Ditschuneit H
Scand J Gastroenterol Suppl. 1987;129:185-91. doi: 10.3109/00365528709095882.
Influence of increased fibre intake on biliary lipids. The influence of dietary fibres (30 g wheat bran per day) on the lithogenicity of the bile was studied in ten healthy persons, whose body weight was 76.8 +/- 2.3 kg, height 189.9 +/- 2.1 cm, age 25.5 +/- 0.26 years. These 10 young male volunteers were given twice daily 15 g wheat bran additionally for six weeks in addition to their normal diet. The bile was obtained endoscopically prepapillarily following stimulation of the gallbladder with ceruletid. The contraction of the gallbladder was controlled sonographically. Increased dietary fibre intake resulted in significant lowering of cholesterol concentration in the bile from 3.27 +/- 0.89 mmol/1 to 2.50 +/- 0.67 mmol/1. The lithogenic index (Admirand and Small, 1968) decreased statistically significant from 1.01 +/- 0.14 to 0.67 +/- 0.11. Total cholesterol and HDL and LDL cholesterol remained unchanged; likewise, there was no change in serum triglyceride and phospholipid concentrations. Hence, an increased intake of dietary fibres of the wheat bran type should be the first dietary measure in both prevention and treatment of cholesterol gallstone disease.
膳食纤维摄入量增加对胆汁脂质的影响。对10名健康男性进行了研究，他们体重76.8±2.3千克，身高189.9±2.1厘米，年龄25.5±0.26岁，旨在探讨膳食纤维（每日30克麦麸）对胆汁致石性的影响。除正常饮食外，这10名年轻男性志愿者每天额外分两次服用15克麦麸，持续六周。用缩胆囊素刺激胆囊后，通过内镜乳头前取胆汁。用超声检查控制胆囊收缩情况。膳食纤维摄入量增加导致胆汁中胆固醇浓度从3.27±0.89毫摩尔/升显著降至2.50±0.67毫摩尔/升。致石指数（Admirand和Small，1968）从1.01±0.14降至0.67±0.11，差异有统计学意义。总胆固醇、高密度脂蛋白和低密度脂蛋白胆固醇保持不变；同样，血清甘油三酯和磷脂浓度也没有变化。因此，增加麦麸类膳食纤维的摄入量应是预防和治疗胆固醇结石病的首要饮食措施。
