Olmarker K, Rydevik B, Dahlin L B, Danielsen N, Nordborg C
Spine (Phila Pa 1976). 1987 Jun;12(5):477-82. doi: 10.1097/00007632-198706000-00011.
An experimental model is described in which collagenase in different concentrations and volumes were applied epidurally or intrathecally in the rabbit lumbar spine. This made it possible to study the tissue effects in a situation similar to that of collagenase leaking from a disc or accidental epidural or intrathecal injection at chemonucleolysis. Epidurally applied collagenase, in higher concentration, caused a local thinning of the dura. This effect was reduced at lower concentrations and volumes. Intrathecally injected collagenase, even in small amounts, caused intrathecal hemorrhage and acute paraplegia in the hind limbs. Therefore, in the clinical situation, intrathecal injection of collagenase must be avoided.
描述了一种实验模型，其中将不同浓度和体积的胶原酶硬膜外或鞘内注射到兔腰椎中。这使得在类似于椎间盘胶原酶泄漏或化学髓核溶解时意外硬膜外或鞘内注射的情况下研究组织效应成为可能。硬膜外应用较高浓度的胶原酶会导致硬脊膜局部变薄。在较低浓度和体积下这种效应会减弱。鞘内注射胶原酶，即使少量，也会导致鞘内出血和后肢急性截瘫。因此，在临床情况下，必须避免鞘内注射胶原酶。
