Malaise M G, Hazee-Hagelstein M T, Reuter A M, Vrinds-Gevaert Y, Goldstein G, Franchimont P
Acta Endocrinol (Copenh). 1987 Aug;115(4):455-60. doi: 10.1530/acta.0.1150455.
Thymopoietin and thymopentin are well characterized polypeptides influencing immunoregulation by several mechanisms. Proposed as a therapy in diseases with major immune abnormalities such as rheumatoid arthritis, thymopentin improved within 2 weeks some clinical parameters as pain and joint swelling. The hypothesis that this spectacular effect could be mediated through interactions with anti-inflammatory (ACTH) and pain relieving (beta-endorphin) hormones producing cells was tested on the rat isolated pituitary cell model. Thymopentin and thymopoietin can enhance in vitro the levels of ACTH, beta-endorphin and beta-lipotropin in a time- and dose-dependent fashion for physiological concentrations ranging from 10(-12) to 10(-8) mol/l. The action on pituitary cells was restricted to those molecules as no changes occurred in LH, FSH, GH, TSH and PRL levels, after otherwise identical experimental conditions.
胸腺生成素和胸腺五肽是特性明确的多肽，可通过多种机制影响免疫调节。胸腺五肽被提议用于治疗类风湿性关节炎等具有主要免疫异常的疾病，在2周内改善了一些临床参数，如疼痛和关节肿胀。在大鼠离体垂体细胞模型上测试了这一显著效果可能通过与抗炎（促肾上腺皮质激素）和止痛（β-内啡肽）激素产生细胞相互作用来介导的假说。对于生理浓度范围为10⁻¹²至10⁻⁸mol/L的情况，胸腺五肽和胸腺生成素可在体外以时间和剂量依赖性方式提高促肾上腺皮质激素、β-内啡肽和β-促脂素的水平。在其他相同实验条件下，对垂体细胞的作用仅限于这些分子，因为促黄体生成素、促卵泡生成素、生长激素、促甲状腺激素和催乳素水平没有变化。
