Lamberts S W, Bons E G, Uitterlinden P, Hackeng W H
J Endocrinol. 1983 Mar;96(3):395-400. doi: 10.1677/joe.0.0960395.
Cyproheptadine and its metabolite desmethylcyproheptadine were shown to suppress directly the release of adrenocorticotrophin (ACTH) and beta-lipotrophin/beta-endorphin activity from the neurointermediate lobe of the pituitary gland incubated in vitro. Neither compound affected the release of ACTH from the anterior pituitary gland. Serotonin stimulated the release of ACTH and beta-lipotrophin/beta-endorphin activity from the neurointermediate lobe, but did not influence the (desmethyl)cyproheptadine-mediated inhibition of hormone release. These results indicate that serotonin and cyproheptadine affect hormone release by the neurointermediate lobe by a direct action. The effect of cyproheptadine, however, might not be exerted by a serotonin receptor.
赛庚啶及其代谢产物去甲基赛庚啶可直接抑制体外培养的垂体神经中间叶促肾上腺皮质激素（ACTH）的释放以及β-促脂素/β-内啡肽的活性。这两种化合物均不影响垂体前叶ACTH的释放。5-羟色胺可刺激神经中间叶释放ACTH以及β-促脂素/β-内啡肽的活性，但不影响（去甲基）赛庚啶介导的激素释放抑制作用。这些结果表明，5-羟色胺和赛庚啶通过直接作用影响神经中间叶的激素释放。然而，赛庚啶的作用可能并非通过5-羟色胺受体发挥。
