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本文引用的文献

1
Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.结核相关免疫重建炎症综合征中结核特异性多功能CD4+ T细胞反应的强劲重建及全身白细胞介素6水平升高
Clin Infect Dis. 2016 Mar 15;62(6):795-803. doi: 10.1093/cid/civ978. Epub 2015 Nov 26.
2
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.CD39表达可识别终末耗竭的CD8 + T细胞。
PLoS Pathog. 2015 Oct 20;11(10):e1005177. doi: 10.1371/journal.ppat.1005177. eCollection 2015 Oct.
3
CD39 is a promising therapeutic antibody target for the treatment of soft tissue sarcoma.CD39是治疗软组织肉瘤的一个有前景的治疗性抗体靶点。
Am J Transl Res. 2015 Jun 15;7(6):1181-8. eCollection 2015.
4
Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: a systematic review and meta-analysis.资源有限环境下HIV感染成人和儿童尸检研究中结核病的患病率：一项系统评价和荟萃分析。
AIDS. 2015 Sep 24;29(15):1987-2002. doi: 10.1097/QAD.0000000000000802.
5
Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study.对开始抗逆转录病毒治疗的合并肺结核的HIV感染成人中与结核病相关的免疫重建炎症综合征和非免疫重建炎症综合征死亡进行免疫分析：一项前瞻性观察队列研究。
Lancet Infect Dis. 2015 Apr;15(4):429-38. doi: 10.1016/S1473-3099(15)70008-3. Epub 2015 Feb 9.
6
Early immunologic failure is associated with early mortality among advanced HIV-infected adults initiating antiretroviral therapy with active tuberculosis.在开始抗逆转录病毒治疗的晚期 HIV 感染成年人中，早期免疫失败与并发活动性肺结核的早期死亡率相关。
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8
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9
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10
Early mortality in adults initiating antiretroviral therapy (ART) in low- and middle-income countries (LMIC): a systematic review and meta-analysis.成人在中低收入国家（LMIC）开始抗逆转录病毒疗法（ART）的早期死亡率：系统评价和荟萃分析。
PLoS One. 2011;6(12):e28691. doi: 10.1371/journal.pone.0028691. Epub 2011 Dec 29.

抗逆转录病毒治疗前CD39+CD8+ T细胞频率升高与晚期人类免疫缺陷病毒/结核病合并感染的早期死亡率相关。

Elevated Pre-Antiretroviral Therapy CD39+CD8+ T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection.

作者信息

Ravimohan Shruthi, Tamuhla Neo, Nfanyana Kebatshabile, Ni Houping, Steenhoff Andrew P, Gross Robert, Weissman Drew, Bisson Gregory P

机构信息

Department of Medicine, Division of Infectious Diseases and.

Botswana-UPenn Partnership, Gaborone.

出版信息

Clin Infect Dis. 2017 May 15;64(10):1453-1456. doi: 10.1093/cid/cix155.

DOI:10.1093/cid/cix155
PMID:28203772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5411394/
Abstract

Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.

摘要

抗逆转录病毒疗法（ART）开始后不久死亡的相关因素仍不清楚。我们研究了新型免疫耗竭标志物CD39的表达与人类免疫缺陷病毒/结核病合并感染患者早期死亡率之间的关联。ART开始前CD39+CD8+T细胞频率升高与ART开始后6个月内的死亡率独立相关。