Department of Immunology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.
Clin Infect Dis. 2017 May 1;64(9):1279-1282. doi: 10.1093/cid/cix140.
STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.
STAT3 高免疫球蛋白 E 综合征（STAT3-HIES）患者的金黄色葡萄球菌特异性血清 IgG 明显低于囊性纤维化患者，尽管金黄色葡萄球菌反复感染。免疫球蛋白替代疗法增加了 STAT3-HIES 患者的金黄色葡萄球菌特异性 IgG，并减轻了疾病的临床过程，表明体液免疫在金黄色葡萄球菌清除中起作用。
