Darisipudi Murthy N, Nordengrün Maria, Bröker Barbara M, Péton Vincent
Department of Immunology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße DZ7, D-17475 Greifswald, Germany.
Microorganisms. 2018 Aug 15;6(3):87. doi: 10.3390/microorganisms6030087.
() is a dangerous pathogen as well as a frequent colonizer, threatening human health worldwide. Protection against infection is challenging, as the bacteria have sophisticated strategies to escape the host immune response. To maintain equilibrium with , both innate and adaptive immune effector mechanisms are required. Dendritic cells (DCs) are critical players at the interface between the two arms of the immune system, indispensable for inducing specific T cell responses. In this review, we highlight the importance of DCs in mounting innate as well as adaptive immune responses against with emphasis on their role in -induced respiratory diseases. We also review what is known about mechanisms that has adopted to evade DCs or manipulate these cells to its advantage.
（）是一种危险的病原体，也是常见的定植菌，对全球人类健康构成威胁。预防感染具有挑战性，因为该细菌具有复杂的策略来逃避宿主免疫反应。为了与（）维持平衡，需要固有免疫和适应性免疫效应机制。树突状细胞（DCs）是免疫系统两条分支之间界面的关键参与者，对于诱导特异性T细胞反应不可或缺。在本综述中，我们强调DCs在针对（）发起固有免疫和适应性免疫反应中的重要性，重点关注它们在（）诱导的呼吸道疾病中的作用。我们还综述了关于（）用于逃避DCs或操纵这些细胞以使其受益的机制的已知情况。
