Bin Ismail Muhammad Amir, Lim Rachel Hui Fen, Fang Helen Mi, Wong Elizabeth Poh Ying, Ling Ho Su, Lim Wee Kiak, Teoh Stephen C, Agrawal Rupesh
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, 308433, Singapore.
Singapore National Eye Centre, Singapore, Singapore.
J Ophthalmic Inflamm Infect. 2017 Dec;7(1):6. doi: 10.1186/s12348-017-0124-5. Epub 2017 Feb 15.
The purpose of this study is to evaluate the spectrum of scleritis from database of Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) at a tertiary eye referral eye institute in Singapore. Clinical records of 120 patients with scleritis from a database of 2200 patients from Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) were reviewed.
56.6% were females, with a mean age of 48.6 ± 15.9 years. 75 (62.5%) had diffuse anterior scleritis, 25 (20.8%) had nodular anterior scleritis, 7 (5.8%) had necrotizing anterior scleritis and 13 (10.8%) had posterior scleritis. Ocular complications were observed in 53.3% of patients, including anterior uveitis (42.5%), raised intraocular pressure (12.5%), and corneal involvement (11.7%). Autoimmune causes were associated with 31 (25.8%) of patients, and 10 (8.3%) patients had an associated infective etiology, much higher than Caucasian studies. 53.3% of patients were treated with oral corticosteroids while 26.7% required immunosuppressives.
Infective etiology needs to be considered in patients of scleritis from Asian origin. In our study and in OASIS database, scleritis was associated with systemic autoimmune disease and ocular complications.
本研究旨在通过新加坡一家三级眼科转诊机构的眼部自身免疫性、系统性、炎症性、感染性研究（OASIS）数据库评估巩膜炎的谱系。回顾了来自OASIS数据库中2200例患者的120例巩膜炎患者的临床记录。
56.6%为女性，平均年龄48.6±15.9岁。75例（62.5%）患有弥漫性前巩膜炎，25例（20.8%）患有结节性前巩膜炎，7例（5.8%）患有坏死性前巩膜炎，13例（10.8%）患有后巩膜炎。53.3%的患者观察到眼部并发症，包括前葡萄膜炎（42.5%）、眼压升高（12.5%）和角膜受累（11.7%）。自身免疫性病因与31例（25.8%）患者相关，10例（8.3%）患者有相关感染病因，远高于高加索人群研究。53.3%的患者接受口服糖皮质激素治疗，26.7%的患者需要免疫抑制剂治疗。
对于亚洲裔巩膜炎患者，需要考虑感染性病因。在我们的研究以及OASIS数据库中，巩膜炎与系统性自身免疫性疾病及眼部并发症相关。
