Ophthalmology Department, Save Sight Institute, Sydney Medical School, University of Sydney , Sydney , Australia.
Centre for Eye Research Australia, Melbourne, Victoria, Australia; Royal Victorian Eye and Ear Hospital, University of Melbourne , Melbourne , Victoria , Australia.
Ocul Immunol Inflamm. 2019;27(6):920-926. doi: 10.1080/09273948.2018.1484496. Epub 2018 Jun 28.
: To examine the spectrum of scleritis in four tertiary institutions across the Asia-Pacific. : Clinical records from 354 patients were reviewed from centers in Australia, Singapore, and India, excluding those with insufficient data ( = 24). : Indian patients presented younger (41.5 ± 13.4 years) than Australians (50.8 ± 17.5) and Singaporeans (48.6 ± 15.9), with fewer women (49% vs 62%/57%). Diffuse disease was universally most common. Autoimmune and infectious disease proportions were similar in Australia (31%/10.3%) and Singapore (27.5%/8.3%) but reversed in India (8.3%/30%). Necrotizing scleritis was most frequently associated with infection (27.3%). Presumed ocular tuberculosis accounted for 75% of infectious cases in India. Posterior scleritis had the highest complication rate (82.4%) and immunosuppressants used per patient (0.98 ± 0.31 95% CI). : Clinical presentations of scleritis vary across the Asia-Pacific, particularly in endemic regions for tuberculosis such as India, where it affects younger men with a predominance of nodular and infectious disease.
: 目的：研究亚太地区四家三级医疗机构的巩膜炎谱。 : 从澳大利亚、新加坡和印度的中心回顾了 354 名患者的临床记录，排除了数据不足的患者（=24 名）。 : 印度患者的年龄明显小于澳大利亚（41.5±13.4 岁）和新加坡（48.6±15.9 岁）患者，女性比例也较低（49%比 62%/57%）。弥漫性疾病是最常见的。在澳大利亚（31%/10.3%）和新加坡（27.5%/8.3%），自身免疫性疾病和感染性疾病的比例相似，但在印度则相反（8.3%/30%）。坏死性巩膜炎最常与感染相关（27.3%）。在印度，推测性眼结核占感染病例的 75%。后巩膜炎的并发症发生率最高（82.4%），每位患者使用的免疫抑制剂也最多（0.98±0.31，95%CI）。 : 巩膜炎的临床表现在亚太地区有所不同，特别是在结核病流行地区，如印度，该病影响年轻男性，以结节性和感染性疾病为主。
