Horne Tamarisk K, Cronjé Marianne J
Department of Biochemistry, Faculty of Science, University of Johannesburg, Auckland Park, South Africa.
Chem Biol Drug Des. 2017 Feb;89(2):221-242. doi: 10.1111/cbdd.12761.
Research within the field of photodynamic therapy has escalated over the past 20 years. The required conjunctional use of photosensitizers, particularly of the macrocycle structure, has lead to a vast repertoire of derivatives that branch classes and subclasses thereof. Each exhibits a differential range of physiochemical properties that influence their potential applications within the larger phototherapy field for use in either diagnostics, photodynamic therapy, both or none. Herein, we provide an overview of these properties as they relate to photodynamic therapy and to a lesser extent diagnostics. By summarizing the mechanistics of photodynamic therapy coupled to the photo-energetics displayed by macrocycle photosensitizers, we aimed to highlight the critical aspects any researcher should be aware of and consider when selecting and performing research for therapeutic application purposes. These include photosensitizer, photophysical and structural properties, synthesis design and subsequent attributes, main applications within research, common shortcomings exhibited and the current methods practiced to overcome them.
在过去20年中，光动力疗法领域的研究不断升级。光敏剂（特别是大环结构的光敏剂）的联合使用，催生了大量的衍生物及其分支类别和亚类。每种衍生物都具有不同的物理化学性质范围，这些性质影响它们在更广泛的光疗领域中的潜在应用，可用于诊断、光动力疗法、两者皆用或两者皆不用。在此，我们概述这些与光动力疗法相关的性质，并在较小程度上涉及诊断。通过总结光动力疗法的机制以及大环光敏剂所表现出的光能量学，我们旨在突出任何研究人员在为治疗应用目的选择和进行研究时应了解和考虑的关键方面。这些方面包括光敏剂、光物理和结构性质、合成设计及后续属性、研究中的主要应用、表现出的常见缺点以及目前用于克服这些缺点的方法。
