Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville.
Clin Infect Dis. 2017 May 15;64(10):1360-1366. doi: 10.1093/cid/cix159.
The epidemiology of penile human papillomavirus (HPV) infection is not well understood. Our objective was to determine the prevalence of penile HPV infection in the United States.
We analyzed a nationally representative sample of civilian noninstitutionalized US men from the National Health and Nutritional Examination Survey (NHANES) 2013-2014. Penile swab samples were collected from men aged 18-59 years. For detection of HPV types, a Roche Linear Array test was performed. We used NHANES sampling weights to estimate the population prevalence of penile HPV infection.
The overall prevalence of any HPV infection was 45.2% (95% confidence interval [CI], 41.3%-49.3%). The prevalence of any high-risk HPV types and low-risk HPV types (mutually exclusive of high-risk HPV) was 30.5% (95% CI, 28.0%-33.0%) and 14.8% (95% CI, 12.7%-17.2%), respectively. Overall HPV prevalence increased with increasing age: the prevalence was lowest among 18- to 24-year-old men (33.8%) and highest among 55- to 59-year-old men (53.4%). HPV types 16 and 18 were detected in 4.3% (95% CI, 3.2%-5.7%) and 1.7% (95% CI, 1.1%-2.6%) of men, respectively. The prevalence of any HPV infection was almost 80% among men who reported having ≥16 lifetime sexual partners and using condoms intermittently.
Our findings indicate that penile HPV is common among men in the United States. Almost one-third of all men are infected with high-risk HPV. Prevalence of penile HPV infection increases with increasing age.
阴茎人乳头瘤病毒（HPV）感染的流行病学尚不清楚。我们的目的是确定美国阴茎 HPV 感染的流行率。
我们分析了来自 2013-2014 年全国健康和营养调查（NHANES）的具有代表性的美国非住院平民男性样本。从 18-59 岁男性中采集阴茎拭子样本。使用罗氏线性阵列试验检测 HPV 类型。我们使用 NHANES 抽样权重来估计阴茎 HPV 感染的人群流行率。
总 HPV 感染率为 45.2%（95%置信区间 [CI]，41.3%-49.3%）。任何高危 HPV 类型和低危 HPV 类型（相互排斥的高危 HPV）的流行率分别为 30.5%（95% CI，28.0%-33.0%）和 14.8%（95% CI，12.7%-17.2%）。总 HPV 流行率随年龄增长而增加：18-24 岁男性的流行率最低（33.8%），55-59 岁男性的流行率最高（53.4%）。HPV 类型 16 和 18 分别在 4.3%（95% CI，3.2%-5.7%）和 1.7%（95% CI，1.1%-2.6%）的男性中检测到。报告有≥16 个性伴侣和间歇性使用避孕套的男性中，任何 HPV 感染的流行率几乎为 80%。
我们的研究结果表明，阴茎 HPV 在美**性中很常见。几乎三分之一的男性感染了高危 HPV。阴茎 HPV 感染的流行率随年龄增长而增加。
