Patel Eshan U, Rositch Anne F, Gravitt Patti E, Tobian Aaron A R
Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
J Infect Dis. 2017 Apr 15;215(8):1207-1211. doi: 10.1093/infdis/jix116.
This study examined the concordance of penile and oral human papillomavirus (HPV) infections in the United States. A total of 1683 men aged 18-59 years who participated in the 2013-2014 National Health and Nutrition Examination Survey and had results of oral and penile HPV DNA testing were examined. The prevalence of any HPV genotype was 45.3% on the penis, 11.2% in the oral cavity, and 8.8% at both sites. The prevalence of HPV in the oral cavity was higher among those with than among those without penile HPV infection (19.3% vs 4.4%; prevalence ratio, 4.37 [95% confidence interval, 2.66-7.16]). The prevalence of ≥1 genotype-concordant HPV infection was 3.2% and was associated with sexual behavior, independent of demographic characteristics and smoking status. Sexual behavior may partly explain the observed association between penile and oral HPV infections.
本研究调查了美国阴茎和口腔人乳头瘤病毒（HPV）感染的一致性。共有1683名年龄在18至59岁之间、参与了2013 - 2014年国家健康与营养检查调查且有口腔和阴茎HPV DNA检测结果的男性接受了检查。任何HPV基因型在阴茎上的患病率为45.3%，在口腔中为11.2%，在两个部位均为8.8%。阴茎有HPV感染的人群中口腔HPV的患病率高于阴茎无HPV感染的人群（19.3%对4.4%；患病率比为4.37 [95%置信区间，2.66 - 7.16]）。≥1种基因型一致的HPV感染患病率为3.2%，且与性行为相关，独立于人口统计学特征和吸烟状况。性行为可能部分解释了观察到的阴茎和口腔HPV感染之间的关联。
