Bunting P S, Szalai J P, Katic M
Department of Biochemistry, Sunnybrook Medical Centre, University of Toronto, Ontario.
Clin Biochem. 1987 Jun;20(3):213-9. doi: 10.1016/s0009-9120(87)80123-6.
Angiotensin converting enzyme (ACE) has been measured in 102 biopsy-proven sarcoid patients, 70 patients diagnosed by clinical and radiological methods and 74 nonsarcoid patients as controls. The distributions of the various groups have been examined, and the effects of stage of disease, disease activity and prednisone treatment have been evaluated. Receiver operating characteristic (ROC) curves have been established for ACE, and the appropriateness of various statistical procedures is discussed. We have not discerned any effect of stage of sarcoidosis or of extent of disease activity on ACE values. The ROC curves suggest an upper limit of normal of about 50 U/L for our assay, and a sensitivity of 63% and specificity of 93%, yielding predictive values of 93% for a positive result and 74% for a negative result, with a likelihood ratio of 3.6. The results are discussed in the context of other work on ACE and in relation to the more invasive procedures of bronchoalveolar lavage and Gallium scan.
对102例经活检证实的结节病患者、70例通过临床和放射学方法诊断的患者以及74例非结节病患者作为对照测定了血管紧张素转换酶（ACE）。检查了各组的分布情况，并评估了疾病分期、疾病活动度和泼尼松治疗的影响。建立了ACE的受试者工作特征（ROC）曲线，并讨论了各种统计程序的适用性。我们没有发现结节病分期或疾病活动程度对ACE值有任何影响。ROC曲线表明，我们的检测方法正常上限约为50 U/L，敏感性为63%，特异性为93%，阳性结果预测值为93%，阴性结果预测值为74%，似然比为3.6。将结合其他关于ACE的研究以及与支气管肺泡灌洗和镓扫描等侵入性更强的检查方法的相关性来讨论这些结果。
