Dover Laura L, Jacob Rojymon, Wang Thomas N, Richardson Joseph H, Redden David T, Li Peng, DuBay Derek A
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Am Surg. 2016 Nov 1;82(11):1133-1139.
Intrahepatic cholangiocarcinoma (ICC) is classified according to the following subtypes: massforming (MF), periductal infiltrating (PI), and intraductal growth (IG). The aim of this study is to measure the association between ICC subtypes and patient survival after surgical resection. Data were abstracted on all patients treated with definitive resections of ICC at a single institution between 2000 and 2011 with at least three years follow-up. Survival estimates were quantified using Kaplan-Meier curves and compared using the log-rank test. There were 37 patients with ICC treated with definitive partial hepatectomies with a median survival of 33.5 months. Tumor stage (P < 0.0001), satellitosis (P < 0.001), lymphovascular space invasion (P = 0.003), and macroscopic subtype (P = 0.003) were predictive of postoperative survival. Disease-free survivals for MF, PI, and IG subtypes, respectively, were 30 per cent, 0 per cent, and 57 per cent (P = 0.017). Overall survivals among ICC macroscopic subtypes were as follows: MF 37 per cent, PI 0 per cent, and IG 71 per cent (P = 0.003). Although limited by the small sample size of this rare cancer, this study demonstrates significant differences among macroscopic subtypes of ICC in both disease-free survivals and overall survivals after definitive partial hepatectomy.
肝内胆管癌（ICC）根据以下亚型进行分类：肿块型（MF）、胆管周围浸润型（PI）和管内生长型（IG）。本研究的目的是衡量ICC亚型与手术切除后患者生存率之间的关联。提取了2000年至2011年在单一机构接受ICC根治性切除术且至少随访三年的所有患者的数据。使用Kaplan-Meier曲线对生存估计进行量化，并使用对数秩检验进行比较。有37例接受根治性部分肝切除术的ICC患者，中位生存期为33.5个月。肿瘤分期（P<0.0001）、卫星灶（P<0.001）、淋巴管间隙侵犯（P=0.003）和大体亚型（P=0.003）可预测术后生存。MF、PI和IG亚型的无病生存率分别为30%、0%和57%（P=0.017）。ICC大体亚型的总生存率如下：MF为37%，PI为0%，IG为71%（P=0.003）。尽管本研究受这种罕见癌症样本量小的限制，但它表明了ICC大体亚型在根治性部分肝切除术后的无病生存率和总生存率方面存在显著差异。
