Salles G, Vital Durand D, Mackiewicz R, Pugeat M, Levrat R
Service de Médecine Interne, Centre Hospitalier Lyon Sud, Pierre-Bénite.
Gastroenterol Clin Biol. 1987 Aug-Sep;11(8-9):607-9.
The case of a 38 year-old man with hepatocellular carcinoma in a non-cirrhotic liver is reported. Hyperestrogenosis with gynecomastia, polycythemia and proteinuria were present. After complete removal of the tumor, estrogen levels, red blood-cell volume and urine analysis did not return to normal and these pathologic findings were probably not paraneoplastic syndromes. Outcome was good, the patient remaining completely well without evidence of recurrence during the ensuing 30 months. The likely explanation for the persistent hyperestrogenosis was an excessive conversion of sexual hormones. The authors suggest that this abnormal hyperestrogenic state could promote hepatic neoplasia as it has been established in animals.
报告了一名38岁非肝硬化性肝细胞癌男性患者的病例。该患者存在雌激素过多症，伴有男子女性型乳房、红细胞增多症和蛋白尿。肿瘤完全切除后，雌激素水平、红细胞体积和尿液分析未恢复正常，这些病理表现可能并非副肿瘤综合征。结果良好，患者在随后的30个月里完全康复，无复发迹象。持续性雌激素过多症的可能解释是性激素过度转化。作者认为，这种异常的高雌激素状态可能会促进肝脏肿瘤的发生，正如在动物研究中所证实的那样。
