Tanaka T, Hoshino Y, Hayashi S, Tanaka S, Tsuruta K, Okamoto A, Koike M, Hattori N
Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Japan.
Hepatogastroenterology. 1996 Sep-Oct;43(11):1390-4.
We reported a very rare case of hepatocellular carcinoma (HCC) developed in a normal liver without persistent hepatitis B or C virus (HBV or HCV) infection. A 39-year-old woman was admitted to our hospital for epigastralgia. Laboratory data demonstrated normal liver function and she had no evidence of past and persistent HBV or HCV infection. Abdominal ultrasonography and abdominal CT scan demonstrated liver tumor of about 40 mm in maximal diameter in the lateral segment. This tumor was moderately differentiated hepatocellular carcinoma (HCC) from the result of operative sample, and the non-tumor area surrounding the HCC was normal pathological finding. The potential integration of HBV DNA into tumor or non tumor cells was not observed. This is a very rare case of hepatocellular carcinoma developed in a normal liver without HBV and HCV infection.
我们报告了一例非常罕见的肝细胞癌（HCC）病例，该病例发生在无持续性乙型或丙型肝炎病毒（HBV或HCV）感染的正常肝脏中。一名39岁女性因上腹部疼痛入住我院。实验室检查数据显示肝功能正常，且无既往及持续性HBV或HCV感染的证据。腹部超声和腹部CT扫描显示肝左外叶有一最大直径约40mm的肝肿瘤。手术标本结果显示该肿瘤为中度分化的肝细胞癌（HCC），HCC周围的非肿瘤区域病理检查结果正常。未观察到HBV DNA潜在整合到肿瘤或非肿瘤细胞中。这是一例在无HBV和HCV感染的正常肝脏中发生肝细胞癌的非常罕见的病例。
