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硫胺素补充剂对乙醇诱导的心脏肥大火鸡雏鸡硫胺素状态的影响。

The effect of thiamin supplementation on the thiamin status of turkey poults with ethanol-induced cardiomegaly.

作者信息

Ali B H, Czarnecki C M

机构信息

Department of Veterinary Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, Sudan.

出版信息

Gen Pharmacol. 1987;18(5):531-3. doi: 10.1016/0306-3623(87)90075-9.

DOI:10.1016/0306-3623(87)90075-9
PMID:2820834
Abstract
  1. Turkey poults were treated with graded doses (0-5% v/v) of ethanol for 6 weeks. Some birds were concomitantly injected intramuscularly with thiamin. 2. Erythrocyte transketolase (TK) activity was significantly decreased and the erythrocyte pyrophosphate (TPP) effect and blood concentrations of lactate and pyruvate were statistically greater in all ethanol-treated poults by 42 days. 3. Thiamin restored TK activity to normal levels and decreased the TPP effect and blood concentrations of lactate and pyruvate in ethanol poults. 4. Thiamin mitigated ethanol-induced cardiomyopathy in some 4-5% ethanol poults. 5. Thiamin had no significant effect on any of these parameters in control birds treated with thiamin.
摘要

  1. 用不同剂量（0 - 5% v/v）的乙醇对火鸡雏进行为期6周的处理。部分禽类同时进行了硫胺素的肌肉注射。

  2. 到42天时，所有经乙醇处理的火鸡雏的红细胞转酮醇酶（TK）活性显著降低，红细胞焦磷酸硫胺素（TPP）效应以及血液中乳酸和丙酮酸的浓度在统计学上显著升高。

  3. 硫胺素使乙醇处理的火鸡雏的TK活性恢复到正常水平，并降低了TPP效应以及血液中乳酸和丙酮酸的浓度。

  4. 硫胺素减轻了部分4 - 5%乙醇处理的火鸡雏的乙醇诱导性心肌病。

  5. 硫胺素对经硫胺素处理的对照禽类的这些参数均无显著影响。

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Gen Pharmacol. 1987;18(5):531-3. doi: 10.1016/0306-3623(87)90075-9.
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