乙醇诱导的幼火鸡硫胺素状态改变。

Ethanol-induced alteration in thiamin status of young turkey poults.

作者信息

Ali B H, Czarnecki C M

出版信息

Gen Pharmacol. 1987;18(2):119-21. doi: 10.1016/0306-3623(87)90236-9.

Abstract

The effect of ethanol on thiamin status was determined in the turkey poult, a new animal model for alcohol-induced cardiomyopathy in humans. The poults were given ethanol (4 to 5% v/v) in the drinking water for six weeks post-hatch. This treatment decreased body weights and increased significantly the relative weights of the hearts. Ethanol consumption increased significantly the blood concentrations of pyruvate and lactate, decreased the activity of erythrocyte transketolase (TK), and increased the stimulation of TK activity of thiamin pyrophosphate (TPP) in lyzed blood cells (TPP effect). These findings indicate that ethanol treatment has an adverse effect on the thiamin status of the turkey poult.

摘要

在火鸡雏禽中测定了乙醇对硫胺素状态的影响，火鸡雏禽是人类酒精性心肌病的一种新动物模型。雏禽在孵化后六周饮用含乙醇（4%至5%体积比）的水。这种处理降低了体重，并显著增加了心脏的相对重量。乙醇摄入显著增加了血液中丙酮酸和乳酸的浓度，降低了红细胞转酮醇酶（TK）的活性，并增加了裂解血细胞中硫胺素焦磷酸（TPP）对TK活性的刺激（TPP效应）。这些发现表明，乙醇处理对火鸡雏禽的硫胺素状态有不利影响。