抗毒力疗法的生物学及未来前景
The biology and future prospects of antivirulence therapies.
作者信息
Cegelski Lynette, Marshall Garland R, Eldridge Gary R, Hultgren Scott J
机构信息
Department of Molecular Microbiology, Washington University, Saint Louis, Missouri 63110, USA.
出版信息
Nat Rev Microbiol. 2008 Jan;6(1):17-27. doi: 10.1038/nrmicro1818.
Abstract
The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics demand the discovery of new therapeutic approaches. Targeting bacterial virulence is an alternative approach to antimicrobial therapy that offers promising opportunities to inhibit pathogenesis and its consequences without placing immediate life-or-death pressure on the target bacterium. Certain virulence factors have been shown to be potential targets for drug design and therapeutic intervention, whereas new insights are crucial for exploiting others. Targeting virulence represents a new paradigm to empower the clinician to prevent and treat infectious diseases.
摘要
对现有抗生素产生耐药性的细菌菌株的出现及其日益普遍，需要发现新的治疗方法。针对细菌毒力是抗菌治疗的一种替代方法，它提供了抑制发病机制及其后果的有前景的机会，而不会对目标细菌施加直接的生死压力。某些毒力因子已被证明是药物设计和治疗干预的潜在靶点，而新的见解对于开发其他毒力因子至关重要。针对毒力代表了一种新的模式，使临床医生有能力预防和治疗传染病。
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