From the Institute for Cardiovascular Prevention (IPEK), Department of Medicine, LMU Munich, Germany (Y.D., O.S., C.W.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany (O.S., C.W.); Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands (O.S.); and Department of Biochemistry, Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands (C.W.).
Circ Res. 2017 Feb 17;120(4):736-743. doi: 10.1161/CIRCRESAHA.116.309692.
Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These net-like structures have also been detected in atherosclerotic lesions and arterial thrombi in humans and mice. Functionally, neutrophil extracellular traps have been shown to induce activation of endothelial cells, antigen-presenting cells, and platelets, resulting in a proinflammatory immune response. Overall, this suggests that they are not only present in plaques and thrombi but also they may play a causative role in triggering atherosclerotic plaque formation and arterial thrombosis. This review will focus on current findings of the involvement of neutrophil extracellular traps in atherogenesis and atherothrombosis.
从自杀性中性粒细胞中排出的中性粒细胞细胞外陷阱包含核染色质和核、颗粒和细胞质来源的蛋白质的复杂结构。这些网状结构也在人类和小鼠的动脉粥样硬化病变和动脉血栓中被检测到。从功能上讲，已经证明中性粒细胞细胞外陷阱会诱导内皮细胞、抗原呈递细胞和血小板的激活，从而引发促炎免疫反应。总的来说，这表明它们不仅存在于斑块和血栓中，而且可能在触发动脉粥样硬化斑块形成和动脉血栓形成中起因果作用。本综述将重点介绍中性粒细胞细胞外陷阱参与动脉粥样硬化形成和动脉血栓形成的最新发现。
