Islam Md Sazedul, Haque Papia, Rashid Taslim U, Khan M Nuruzzaman, Mallik Abul K, Khan M Nazrul I, Khan Mala, Rahman Mohammed Mizanur
Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering and Technology, University of Dhaka, Dhaka, 1000, Bangladesh.
Material Science Division, Atomic Energy Centre, Bangladesh Atomic Energy Commission, Dhaka, 1000, Bangladesh.
J Mater Sci Mater Med. 2017 Apr;28(4):55. doi: 10.1007/s10856-017-5859-x. Epub 2017 Feb 16.
A multifunctional drug carrier with dual targeting (magnetic and folate-receptor) and pH sensitive core-shell hybrid nanomaterial has been developed to carry an anticancer drug doxorubicin.Superparamagnetic iron oxide nanoparticles (IONPs) were used as core of the carrier and cross-linked folate conjugated chitosan (FA-CS) was acted as shell in which doxorubicin was physically entrapped. Transmission electron microscopy (TEM) analysis confirmed the average particle size of IONPs and FA-CS coated IONPs 8.2 and 15.4 nm respectively. Magnetic measurement indicated that both the IONPs and FA-CS coated IONPs were superparamagnetic at room temperature with a magnetization value 57.72 and 37.44 emu/g respectively. At pH 5.8 (malignant tissue) showed a burst release of 30.05% of the doxorubicin in the first 4 h followed by a sustained release of 88.26% of drug over 72 h. From these results it is expected that doxorubicin loaded nanoparticles can be a promising drug carrier for the treatment of solid tumors with the ability to reduce toxic side effects of drugs by selective targeting and sustained release.
一种具有双靶向（磁性和叶酸受体）和pH敏感核壳杂化纳米材料的多功能药物载体已被开发用于携带抗癌药物阿霉素。超顺磁性氧化铁纳米颗粒（IONPs）用作载体的核心，交联叶酸共轭壳聚糖（FA-CS）用作壳，阿霉素物理包裹在其中。透射电子显微镜（TEM）分析证实IONPs和FA-CS包覆的IONPs的平均粒径分别为8.2和15.4nm。磁性测量表明，IONPs和FA-CS包覆的IONPs在室温下均为超顺磁性，磁化值分别为57.72和37.44emu/g。在pH 5.8（恶性组织）时，阿霉素在前4小时内突发释放30.05%，随后在72小时内持续释放88.26%的药物。从这些结果可以预期，负载阿霉素的纳米颗粒有望成为治疗实体瘤的药物载体，具有通过选择性靶向和持续释放降低药物毒副作用的能力。
