Clinical Trials and Biostatistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Melbourne EpiCentre, University of Melbourne and Melbourne Health, Melbourne, Australia.
Diabetes Obes Metab. 2017 Jul;19(7):1014-1023. doi: 10.1111/dom.12915. Epub 2017 Mar 17.
To investigate the probability of developing type 2 diabetes mellitus (T2DM) at different body mass index levels compared to matched non-diabetic controls in a multi-ethnic population.
This was a case-control study of 90 367 patients with incident diabetes and 362 548 age-sex-ethnicity matched controls from UK primary care. The probability of developing T2DM was estimated.
Case and control patients were 56 years old at index and 56% were male. Patients with T2DM had significantly higher mean BMI levels by about 5 kg/m at diagnosis (32.2 kg/m ) compared to the matched controls (27.4 kg/m ). White Europeans (n = 79 270), African-Caribbeans (n = 4115) and South Asians (n = 7252) were 58, 48 and 46 years old with a mean BMI of 32.5, 31.1 and 29.2 kg/m , respectively, at diagnosis. More South Asians developed T2DM at BMI below 30 kg/m (38%) than White Europeans (26%) and African-Caribbeans (29%) (all P < .01). Within the 18 to 70-year age range, South Asian males and females had a significantly higher probability of developing diabetes in the continuously measured BMI range of 18 to 30 kg/m , compared to White Europeans and African-Caribbeans. Across all age groups <70 years, South Asians and African-Caribbeans had a significantly higher probability of developing T2DM in the normal weight and overweight categories, compared to White Europeans. However, this risk pattern of developing diabetes was reversed amongst the obese in all age groups.
Risk patterns of developing diabetes at different levels of obesity varies among ethnic groups across all ages, while South Asians and African-Caribbeans carry the highest risk at a younger age and at lower adiposity burden.
在一个多民族人群中，与匹配的非糖尿病对照相比，比较不同体重指数水平发生 2 型糖尿病（T2DM）的概率。
这是一项针对英国初级保健中 90367 例新发糖尿病患者和 362548 例年龄、性别和种族匹配对照的病例对照研究。估计了发生 T2DM 的概率。
病例和对照患者的索引年龄为 56 岁，56%为男性。与匹配的对照组（27.4kg/m2）相比，T2DM 患者的平均 BMI 水平在诊断时高出约 5kg/m2（32.2kg/m2）。白种欧洲人（n=79270）、非洲裔加勒比人（n=4115）和南亚人（n=7252）的年龄分别为 58、48 和 46 岁，诊断时的平均 BMI 分别为 32.5、31.1 和 29.2kg/m2。与白种欧洲人（26%）和非洲裔加勒比人（29%）相比，更多的南亚人在 BMI 低于 30kg/m2 时发生 T2DM（38%）（均 P<.01）。在 18 至 70 岁的年龄范围内，南亚男性和女性在 18 至 30kg/m2 的连续测量 BMI 范围内发生糖尿病的概率明显高于白种欧洲人和非洲裔加勒比人。在所有年龄组（<70 岁）中，与白种欧洲人相比，南亚人和非洲裔加勒比人在正常体重和超重类别中发生 T2DM 的概率明显更高。然而，在所有年龄组的肥胖人群中，这种发生糖尿病的风险模式发生了逆转。
不同肥胖水平发生糖尿病的风险模式在所有年龄段的不同种族之间存在差异，而南亚人和非洲裔加勒比人在较年轻和较低肥胖负担时风险最高。
