Cennamo G, Romano M R, Breve M A, Velotti N, Reibaldi M, de Crecchio G, Cennamo G
Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.
Eye Clinic, University of Catania, Catania, Italy.
Eye (Lond). 2017 Jun;31(6):906-915. doi: 10.1038/eye.2017.14. Epub 2017 Feb 17.
AimTo describe the vascular features of choroidal tumors using enhanced depth imaging (EDI), optical coherence tomography (OCT), and OCT-angiography.MethodsIn this prospective study, we evaluated 116 Caucasian patients with choroidal tumors (60 eyes with choroidal nevi, 40 with choroidal melanoma, 6 with choroidal hemangioma, 2 with optic disc melanocytoma, 6 with choroidal osteoma, and 2 with retinal metastases). Patients underwent a complete ophthalmic examination including bulbar echography, EDI-OCT, OCT-angiography, and multicolor imaging. Sixteen patients also underwent fluorescein and indocyanine angiography.ResultsThe left eye was more involved than the right eye. The mean tumor thickness was 1.23±0.17 mm in the 60 eyes with choroidal nevi; 2.75±0.83 mm in the 40 eyes with choroidal melanoma; 3.28±0.78 mm in the 6 eyes with retinal angioma; 2.02±0.001 mm in the 2 eyes with optic disc melanocytoma; 2.40±0.31 mm in the 6 eyes with choroidal osteoma; and last, 3.49±0.001 mm in the 2 eyes with retinal metastases. OCT-angiography showed: (i) a lack of blood flow in the outer retinal layer (ORL) and a normal choroid capillary layer in choroidal nevi and optic disc melanocytomas; (ii) a lack of blood flow in the ORL of choroidal metastases; and (iii) a dense irregular vascular network in the ORL and choroid capillary layers of choroidal melanomas, choroidal hemangiomas, and choroidal osteomas.ConclusionsOCT-angiography is a noninvasive reliable method with which to evaluate the vascularization of small choroidal tumors and may improve the diagnosis of these tumors.
使用增强深度成像（EDI）、光学相干断层扫描（OCT）和OCT血管造影来描述脉络膜肿瘤的血管特征。
在这项前瞻性研究中，我们评估了116例患有脉络膜肿瘤的白种人患者（60只眼患有脉络膜痣，40只眼患有脉络膜黑色素瘤，6只眼患有脉络膜血管瘤，2只眼患有视盘黑色素细胞瘤，6只眼患有脉络膜骨瘤，2只眼患有视网膜转移瘤）。患者接受了包括眼球超声检查、EDI-OCT、OCT血管造影和多色成像在内的完整眼科检查。16例患者还接受了荧光素和吲哚菁绿血管造影。
左眼受累比右眼更常见。60只患有脉络膜痣的眼中，肿瘤平均厚度为1.23±0.17毫米；40只患有脉络膜黑色素瘤的眼中，为2.75±0.83毫米；6只患有脉络膜血管瘤的眼中，为3.28±0.78毫米；2只患有视盘黑色素细胞瘤的眼中，为2.02±0.001毫米；6只患有脉络膜骨瘤的眼中为2.40±0.31毫米；最后，2只患有视网膜转移瘤的眼中为3.49±0.001毫米。OCT血管造影显示：（i）脉络膜痣和视盘黑色素细胞瘤中外层视网膜层（ORL）无血流，脉络膜毛细血管层正常；（ii）脉络膜转移瘤的ORL无血流；（iii）脉络膜黑色素瘤、脉络膜血管瘤和脉络膜骨瘤的ORL和脉络膜毛细血管层有密集不规则血管网络。
OCT血管造影是一种评估小脉络膜肿瘤血管化的非侵入性可靠方法，可能会改善这些肿瘤的诊断。
