Di Gong, Weihong Yu, Xiao Zhang, Zhikun Yang, Xuan Zou, Yi Qu, Fangtian Dong
Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuaifuyuan No. 1 Dongcheng District, Beijing, 100730, China.
Graefes Arch Clin Exp Ophthalmol. 2016 May;254(5):873-9. doi: 10.1007/s00417-015-3143-7. Epub 2015 Sep 7.
To investigate the area and radius of the foveal avascular zone (FAZ) in patients with diabetes mellitus (DM) using optical coherence tomography (OCT) angiography.
Sixty-five patients with DM (113 eyes) and 62 healthy controls (85 eyes) were included in the study. All of the participants underwent examination with OCT angiography. The vertical radius (VR), horizontal radius (HR) and area of the FAZ were measured.
The differences in HR, VR and area between the control and DM groups were statistically significant (p = 0.01, 0.00 and 0.00, respectively). There were no statistically significant differences between the control group and the no-diabetic retinopathy (DR) group in HR or VR (p = 0.07 and 0.08, respectively), but there was a statistically significant difference in area (p = 0.04). The size of the FAZ was greater in patients with DR compared to the control group. The differences in HR, VR and area were statistically significant (p = 0.01, 0.00 and 0.00, respectively). In addition, the clinically significant macular oedema (CSME) group also had a larger FAZ area than the non-CSME group (p = 0.02).
Patients with DM had a larger FAZ, and patients with more severely damaged retinas had a much larger FAZ. OCT angiography is a new convenient and noninvasive method for studying the FAZ. This novel examination will yield considerable amounts of data that cannot be obtained using previous research methods.
使用光学相干断层扫描血管造影术（OCT血管造影）研究糖尿病（DM）患者的黄斑无血管区（FAZ）的面积和半径。
本研究纳入了65例DM患者（113只眼）和62例健康对照者（85只眼）。所有参与者均接受了OCT血管造影检查。测量了FAZ的垂直半径（VR）、水平半径（HR）和面积。
对照组与DM组之间的HR、VR和面积差异具有统计学意义（分别为p = 0.01、0.00和0.00）。对照组与非糖尿病视网膜病变（DR）组之间的HR或VR无统计学显著差异（分别为p = 0.07和0.08），但面积存在统计学显著差异（p = 0.04）。与对照组相比，DR患者的FAZ尺寸更大。HR、VR和面积的差异具有统计学意义（分别为p = 0.01、0.00和0.00）。此外，临床显著性黄斑水肿（CSME）组的FAZ面积也大于非CSME组（p = 0.02）。
DM患者的FAZ更大，视网膜损伤更严重的患者的FAZ要大得多。OCT血管造影是一种研究FAZ的新型便捷且无创的方法。这种新颖的检查将产生大量使用先前研究方法无法获得的数据。
