1The Rothman Institute at Thomas Jefferson University, Philadelphia, PA; and 2Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA.
Med Sci Sports Exerc. 2017 Mar;49(3):396-402. doi: 10.1249/MSS.0000000000001120.
Rotator cuff pathology has been proposed to occur through intrinsic and extrinsic mechanisms. Hyperlipidemia has been proposed as a mechanism of intrinsic rotator cuff pathology. This prospective observational study evaluates serum and synovial lipid profiles in patients with and without rotator cuff tears to further define the relationship of cholesterol and rotator cuff pathology.
Patients were prospectively enrolled with intact rotator cuff (37 patients) and rotator cuff tear requiring a repair (40 patients) groups. Exclusion criteria were medication for hypercholesterolemia, smoking, previous ipsilateral shoulder surgery, inflammatory arthritis, or history of shoulder infection. Serum and synovial fluid samples were collected at the time of surgery and analyzed for total cholesterol, HDL, non-HDL, and triglycerides.
There were no significant differences seen in any lipid values between patients with rotator cuff and those without a tear. The calculated ratio of synovial lipids to serum lipids was also not significantly different between the patient groups with and without cuff tears.
This study successfully evaluates the correlation between serum and synovial lipid levels in the glenohumeral joint. The ratio of lipid values between the serum and the synovial fluid was similar, thus defining a ratio of lipid levels between the blood and the shoulder joint regardless of the presence of a rotator cuff tear. All lipid values measured were similar in both the serum and synovial fluid between patients with and without cuff tears.
肩袖病变的发生机制包括内在因素和外在因素。高血脂被认为是内在肩袖病变的机制之一。本前瞻性观察研究旨在评估患有和不患有肩袖撕裂的患者的血清和滑膜脂质谱，以进一步明确胆固醇与肩袖病变的关系。
前瞻性纳入肩袖完整（37 例）和肩袖撕裂需修复（40 例）的患者。排除标准为服用降胆固醇药物、吸烟、同侧肩部手术史、炎性关节炎或肩部感染史。在手术时采集血清和滑膜液样本，并分析总胆固醇、高密度脂蛋白、非高密度脂蛋白和甘油三酯。
肩袖撕裂患者与无撕裂患者的任何脂质值均无显著差异。有和无肩袖撕裂患者的滑膜脂质与血清脂质比值也无显著差异。
本研究成功评估了盂肱关节中血清和滑膜脂质水平之间的相关性。血清和滑液之间的脂质值比值相似，因此定义了血液与肩关节之间的脂质水平比值，而与肩袖撕裂的存在无关。有和无肩袖撕裂的患者的血清和滑膜液中的所有脂质值均相似。
