Department of Pathology, Ajou University School of Medicine, Suwon, Republic of Korea.
Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, 206 Worldcup-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 16499, Republic of Korea.
Lung Cancer. 2017 Feb;104:31-37. doi: 10.1016/j.lungcan.2016.12.003. Epub 2016 Dec 15.
We evaluated glucose transporter type 1 (GLUT1) and carbonic anhydrase IX (CAIX) expression, together with volume-basedF-fluorodeoxyglucose positron emission tomography (FDG-PET) parameters, in non-small cell lung cancer (NSCLC) patients, and examined the prognostic significance of those parameters according to its histologic subtype.
A total of 269 patients, who underwent surgical resection for NSCLC, were reviewed retrospectively. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were measured by preoperative F-fluorodeoxyglucose positron emission tomography computed tomography. GLUT1 and CAIX expression was evaluated using immunohistochemical method.
The mean MTV and TLG values were 30.0±57.1 and 165.4±361.3, respectively, and were significantly higher in patients with squamous cell carcinoma than with adenocarcinoma (p=0.047 for MTV; p=0.042 for TLG). GLUT1 expression was identified in 99% of squamous cell carcinoma and 50% of adenocarcinoma patients. MTV and TLG values were significantly higher in GLUT1-positive than GLUT-negative adenocarcinomas; however, CAIX expression did not show this pattern. GLUT1-positive adenocarcinoma patients had a lower OS than GLUT1-negative patients (p<0.001), whereas CAIX-positive and CAIX-negative patients showed similar OS rates (p=0.226). Patients with high MTV and TLG values showed lower OS rates than those with low MTV and TLG values. Multivariate analysis showed that GLUT1 positivity was an independent risk factor for a lower OS rate in lung adenocarcinoma patients (hazard ratio=2.574, p=0.016). GLUT1 expression was associated with micropapillary/solid histology, lymphovascular invasion, and advanced pTNM stage.
MTV and TLG values, and GLUT1 expression, significantly differed between patients with squamous cell carcinoma and adenocarcinoma. High GLUT1 expression levels were significantly associated with MTV and TLG values and adverse clinical outcomes in patients with adenocarcinoma.
我们评估了葡萄糖转运蛋白 1（GLUT1）和碳酸酐酶 9（CAIX）的表达，以及非小细胞肺癌（NSCLC）患者的基于体积的 F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）参数，并根据其组织学亚型检查了这些参数的预后意义。
回顾性分析了 269 例接受 NSCLC 手术切除的患者。使用术前 F-氟脱氧葡萄糖正电子发射断层扫描计算机断层扫描测量代谢肿瘤体积（MTV）和总病变糖酵解（TLG）值。使用免疫组织化学方法评估 GLUT1 和 CAIX 的表达。
平均 MTV 和 TLG 值分别为 30.0±57.1 和 165.4±361.3，鳞状细胞癌患者明显高于腺癌患者（MTV 为 p=0.047；TLG 为 p=0.042）。99%的鳞状细胞癌和 50%的腺癌患者表达 GLUT1。GLUT1 阳性的腺癌患者的 MTV 和 TLG 值明显高于 GLUT1 阴性的腺癌患者；然而，CAIX 表达没有这种模式。GLUT1 阳性的腺癌患者的 OS 低于 GLUT1 阴性的患者（p<0.001），而 CAIX 阳性和 CAIX 阴性的患者的 OS 率相似（p=0.226）。MTV 和 TLG 值较高的患者的 OS 率低于 MTV 和 TLG 值较低的患者。多因素分析显示，GLUT1 阳性是肺腺癌患者 OS 率降低的独立危险因素（风险比=2.574，p=0.016）。GLUT1 表达与微乳头状/实体组织学、血管淋巴管侵犯和晚期 pTNM 分期有关。
鳞状细胞癌和腺癌患者的 MTV 和 TLG 值以及 GLUT1 表达明显不同。在腺癌患者中，高 GLUT1 表达水平与 MTV 和 TLG 值以及不良临床结局显著相关。
