Karaman Elanur, Goksel Sibel, Tuluce Kerim
Department of Medical Oncology, Recep Tayyip Erdogan University Education and Research Hospital, Rize, Turkey.
Department of Nuclear Medicine, Recep Tayyip Erdogan University Education and Research Hospital, Rize, Turkey.
J Coll Physicians Surg Pak. 2022 Jun;32(6):740-745. doi: 10.29271/jcpsp.2022.06.740.
To evaluate the effect of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values of the primary tumor measured by preoperative positron emission tomography/computed tomography (FDG-PET/CT) on survival in patients with operated non-small cell lung cancer (NSCLC).
Cohort study.
Recep Tayyip Erdogan University, Faculty of Medicine, Department of Medical Oncology from January 2017 to June 2020, Turkey.
Patients with operated NSCLC were reviewed retrospectively. Metabolic parameters of FDG-PET/CT such as pathological tumor features, type of operation, MTV/TLG values, and whether they received adjuvant therapy were evaluated. Disease-free survival (DFS) and overall survival (OS) times were calculated.
Most of the 77 patients (96.1%) were male. The mean age is 64±8 years. Lobectomy was performed in 66 (85.7%) patients, and pneumonectomy was performed in 11 (14.3%) patients. The mean tumor diameter was 3.7±2.015cm. Squamous cell carcinoma was detected in 37 patients (48.1%) and adenocarcinoma in 35 patients (45.5%). Thirty-eight patients (49.4%) received adjuvant chemotherapy. SUVmax, MTV, and TLG values of the primary tumor were high in patients under 65 years of age and with a tumor diameter of ≥3cm. DFS was nine months (4.5-18), and OS was 19 months (11-29). The 2-year survival rate was 75.6%. It was observed that patients with adenocarcinoma relapsed more frequently, which negatively affected survival (p=0.023, and p=0.024 respectively). High MTV (p=0.01) and TLG (p=0.015) values were associated with poor prognosis.
NSCLC is a heterogeneous disease, and survival is affected by many factors. Our study showed that the subtype of adenocarcinoma and high MTV and TLG values of the primary tumor are poor prognostic factors in operated early-stage lung cancers.
Early-stage, Non-small cell lung cancer, MTV, TLG, NSCLC, Survival, FDG-PET/CT.
评估术前正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）测量的原发性肿瘤代谢肿瘤体积（MTV）和总病变糖酵解（TLG）值对接受手术的非小细胞肺癌（NSCLC）患者生存的影响。
队列研究。
2017年1月至2020年6月，土耳其雷杰普·塔伊普·埃尔多安大学医学院医学肿瘤学系。
对接受手术的NSCLC患者进行回顾性研究。评估FDG-PET/CT的代谢参数，如病理肿瘤特征、手术类型、MTV/TLG值以及他们是否接受辅助治疗。计算无病生存期（DFS）和总生存期（OS）。
77例患者中的大多数（96.1%）为男性。平均年龄为64±8岁。66例（85.7%）患者行肺叶切除术，11例（14.3%）患者行全肺切除术。平均肿瘤直径为3.7±2.015cm。37例（48.1%）患者检测到鳞状细胞癌，35例（45.5%）患者检测到腺癌。38例（49.4%）患者接受了辅助化疗。65岁以下且肿瘤直径≥3cm的患者原发性肿瘤的SUVmax、MTV和TLG值较高。DFS为9个月（4.5-18），OS为19个月（11-29）。2年生存率为75.6%。观察到腺癌患者复发更频繁，这对生存产生了负面影响（分别为p=0.023和p=0.024）。高MTV（p=0.01）和TLG（p=0.015）值与预后不良相关。
NSCLC是一种异质性疾病，生存受多种因素影响。我们的研究表明，腺癌亚型以及原发性肿瘤的高MTV和TLG值是早期肺癌手术后的不良预后因素。
早期；非小细胞肺癌；MTV；TLG；NSCLC；生存；FDG-PET/CT
