Klunder Leon J, Faber Klaas Nico, Dijkstra Gerard, van IJzendoorn Sven C D
Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a027888. doi: 10.1101/cshperspect.a027888.
Intestinal epithelial cell polarity is instrumental to maintain epithelial homeostasis and balance communications between the gut lumen and bodily tissue, thereby controlling the defense against gastrointestinal pathogens and maintenance of immune tolerance to commensal bacteria. In this review, we highlight recent advances with regard to the molecular mechanisms of cell polarity-controlled epithelial homeostasis and immunity in the human intestine.
肠上皮细胞极性有助于维持上皮稳态，并平衡肠腔与身体组织之间的通讯，从而控制对胃肠道病原体的防御以及对共生细菌免疫耐受性的维持。在本综述中，我们重点介绍了关于细胞极性控制的上皮稳态和人类肠道免疫的分子机制的最新进展。
